{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:29:19Z","timestamp":1785882559178,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>HIV infection is associated with increased risk of erectile dysfunction (ED); however, factors associated with ED remain unclear. We evaluated the prevalence of ED among men living with HIV and factors associated with ED diagnosis in the US Military HIV Natural History Study (NHS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study evaluated participants in the NHS, a cohort of HIV\u2010positive active duty members and beneficiaries with HIV infection. Men with a diagnosis of ED after HIV diagnosis were included. Cohort controls without ED diagnosis were matched 2:1 by age at HIV diagnosis and duration of follow\u2010up. Multivariate logistic regression models were used to identify factors associated with ED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 543 of 5682 male participants (9.6% prevalence) had a diagnosis of ED, of whom 488 were included in the analysis. The median (interquartile range, IQR) age at ED diagnosis was 43 (37.0\u201349.0) years and the time from HIV diagnosis to antiretroviral therapy (ART) start was longer for cases (5.0\u00a0years, IQR: 2.0\u20139.0) than for controls (3.0\u00a0years, 1.0\u20136.0; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Cases had higher proportions of multiple comorbid conditions, including depression (33.4% <jats:italic>vs<\/jats:italic>. 21.7%), tobacco use (19.7% <jats:italic>vs<\/jats:italic>. 9.0%) and sleep apnoea (14.8% <jats:italic>vs<\/jats:italic>. 4.2%) compared with controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 for all). Logistic regression showed increased odds of ED for delayed ART initiation\u00a0&gt;\u00a04\u00a0years [odds ratio (OR) = 2.05, 95% confidence interval (CI): 1.56\u20132.71], protease inhibitor use\u00a0\u2265\u00a01\u00a0year (OR = 1.81, 95% CI: 1.38\u20132.38) and sleep apnoea (OR = 2.60, 95% CI: 1.68\u20134.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Erectile dysfunction was common in men with HIV and associated factors included both HIV\u2010related and traditional factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13107","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T03:45:37Z","timestamp":1619408737000},"page":"617-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Factors associated with erectile dysfunction diagnosis in men with HIV infection: a case\u2013control study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-196X","authenticated-orcid":false,"given":"N","family":"Jansen","sequence":"first","affiliation":[{"name":"San Antonio Military Medical Center San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Sociology University of Texas San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sunil","sequence":"additional","affiliation":[{"name":"Department of Sociology University of Texas San Antonio San Antonio TX USA"},{"name":"West China School of Public Health Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Sociology University of Texas San Antonio San Antonio TX USA"},{"name":"School of Public Administration Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Cota","sequence":"additional","affiliation":[{"name":"San Antonio Military Medical Center San Antonio TX USA"},{"name":"University of the Incarnate Word Feik School of Pharmacy San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Research Program Department of Preventive Medicine and Biostatistics Uniformed Services University of Health Sciences Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5114-1669","authenticated-orcid":false,"given":"BK","family":"Agan","sequence":"additional","affiliation":[{"name":"Infectious Disease Clinical Research Program Department of Preventive Medicine and Biostatistics Uniformed Services University of Health Sciences Rockville MD USA"},{"name":"The Henry M. 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