{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:23:46Z","timestamp":1776777826588,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Immune reconstitution inflammatory syndrome (IRIS) is a major concern when starting antiretroviral therapy (ART) in patients with advanced HIV infection. The aim of this study was to determine the incidence and risk factors of IRIS in HIV\u2010infected Koreans initiating ART, and whether integrase strand transfer inhibitor (INSTI) treatment increases the risk of IRIS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective analysis included adults living with HIV, seen at four university\u2010affiliated hospitals in South Korea, who were na\u00efve to ART and had a CD4 T\u2010cell count &lt;\u00a0200 cells\/\u03bcL between January 2004 and May 2019. IRIS was determined through a medical record review within 6\u00a0months of ART initiation. Propensity score\u2010matched case\u2013control study between the non\u2010INSTI and INSTI groups was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 501 patients; 192 were assigned to the INSTI group, who started ART based on INSTIs as the initial treatment. There were opportunistic infections (OIs) in 253 (50.5%) cases before ART initiation. The three most common OIs were <jats:italic>Pneumocystis<\/jats:italic> <jats:italic>jirovecii<\/jats:italic> pneumonia, candidiasis and tuberculosis (TB). We identified 47 cases of IRIS; TB\u2010IRIS was the most common type. The incidence of IRIS within 6\u00a0months of ART initiation was 9.4%, and there were no significant differences in baseline characteristics and incidence of IRIS between the matched groups. The risk factors for IRIS were pre\u2010ART CD4 T\u2010cell count (&lt;\u00a030\u00a0cells\/\u03bcL), higher pre\u2010ART viral load (\u2265\u00a075\u00a0000 copies\/mL), and TB\u2010OI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of IRIS was 9.4% in Korean HIV patients. The INSTI regimen was not related to IRIS occurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13117","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T08:20:58Z","timestamp":1622190058000},"page":"705-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Integrase strand transfer inhibitor treatment does not increase the incidence of immune reconstitution inflammatory syndrome in HIV\u2010infected Koreans"],"prefix":"10.1111","volume":"22","author":[{"given":"J","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Chonnam National University Medical School Chonnam National University Hospital Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u2010J","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chonnam National University Medical School Chonnam National University Hospital Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u2010J","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chonnam National University Medical School Chonnam National University Hospital Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u2010I","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chonnam National University Medical School Chonnam National University Hospital Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CH","family":"Hwang","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute Chonnam National University Hospital Gwangju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u2010S","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University Medical School Deajeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u2010H","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyungpook National University School of Medicine Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u2010W","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyungpook National University School of Medicine Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u2010Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Chonnam National University Medical School Chonnam National University Hospital Gwangju 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