{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T22:12:12Z","timestamp":1782339132748,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Many individuals living with HIV use natural health products (NHPs) in an effort to decrease medication side effects and to enhance overall well\u2010being.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An active surveillance study of adult patients (\u2265\u00a018\u00a0years) with HIV was conducted between 2012 and 2014 to detect prescription drug and NHP use and associated adverse events (AEs) in the last month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 167 participants, 85 (50.9%) took prescription medications only, three (1.8%) took NHPs only, 75 (44.9%) took NHPs and prescription medications concurrently, and four (2.4%) took neither. Patients who used both prescription drugs and NHPs concurrently were more than three times more likely to experience an AE compared with those who used prescription drugs only (OR, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.003, 95% CI: 1.47\u20136.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased AEs are reported in patients with HIV who combine NHPs and prescription medications, and no serious AEs were reported. Active surveillance was found to be feasible in this clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13155","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T18:09:33Z","timestamp":1629914973000},"page":"29-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Study of natural product adverse events in adult HIV\u2010infected patients in Canada"],"prefix":"10.1111","volume":"23","author":[{"given":"Emma","family":"Sparks","sequence":"first","affiliation":[{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Zorzela","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Necyk","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medicine and Psychiatry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-7933","authenticated-orcid":false,"given":"Sunita","family":"Vohra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medicine and Psychiatry University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Health Canada.Adulteration of natural health products [internet].2011. Available from:https:\/\/www.canada.ca\/en\/health\u2010canada\/services\/healthy\u2010living\/your\u2010health\/medical\u2010information\/adulteration\u2010natural\u2010health\u2010products.html#issue"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049676"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X12451056"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2008.00610.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106882\u201013\u201080"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H463"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462054093962"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja11.10698"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.02.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr248"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.171409"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06413-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/135965350701200808"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/507894"},{"key":"e_1_2_9_16_1","unstructured":"GardinerP ShaughnessyA PhillipsR.Herbal and dietary supplement\u2010drug interactions in patients with chronic illnesses \u2010 American Family Physician.2008;(February). Available from: file:\/\/\/I:\/Herbal and Dietary Supplement\u2010Drug Interactions in Patients with Chronic Illnesses \u2010 American Family Physician.htm"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462416671087"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-014-0212-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_9_20_1","unstructured":"Government of Canada.Natural and non\u2010prescription health products[Internet].2015[cited 2018 May 13]. Available from:https:\/\/www.canada.ca\/en\/health\u2010canada\/services\/drugs\u2010health\u2010products\/natural\u2010non\u2010prescription.html"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2016.1174109"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"71","article-title":"ICH E2A \u2010 Clinical safety data managements: definitions and standards for expedited reporting","volume":"23","author":"European Medicines Agency","year":"2010","journal-title":"Drug News."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2020-000674"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045196"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2136-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201956"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4169"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.1320"},{"key":"e_1_2_9_29_1","unstructured":"NIH.CTCAE common terminology criteria adverse events. Natl Inst Heal Natl Cancer Inst [Internet]. 2017;0\u201371. Available from:https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_8.5x11.pdf%0Ahttp:\/\/www.uptodate.com\/contents\/common\u2010terminology\u2010criteria\u2010for\u2010adverse\u2010events"},{"key":"e_1_2_9_30_1","unstructured":"Marketed Health Products Directorate.Draft consensus guidelines pharacovgiliance planning[Internet]. Health Canada. 2003 [cited 2019 May 21]. Available from:https:\/\/www.canada.ca\/en\/health\u2010canada\/services\/drugs\u2010health\u2010products\/reports\u2010publications\/medeffect\u2010canada\/reporting\u2010adverse\u2010reactions\u2010marketed\u2010health\u2010products\u2010guidance\u2010industry.html"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_9_32_1","volume-title":"Stata Statistical Software","author":"StataCorp","year":"2015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203890"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010016\u20101177\u20108"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir626"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1865\u20101380\u20104\u201022"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.1415"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003431"},{"key":"e_1_2_9_39_1","unstructured":"World Health Organization.The Importance of Pharmacovigilance\u202f: safety monitoring of medicinal products.2002. 49 p."},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.73.7.795"},{"key":"e_1_2_9_41_1","article-title":"Active surveillance in community pharmacies: qualitative and quantitative data of Adverse Reaction case reports","author":"Vohra S","year":"2009","journal-title":"Heal Canada."},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2016.1174109"},{"key":"e_1_2_9_43_1","unstructured":"Canadian Safety Institute.Best possible medication history[Internet]. 2016 [cited 2018 Aug 2]. Available from:http:\/\/www.patientsafetyinstitute.ca\/en\/Topic\/Pages\/Best\u2010Possible\u2010Medication\u2010History.aspx"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540120701767216"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/108729103321619764"},{"key":"e_1_2_9_46_1","unstructured":"U.S. Department of Health and Human Services.Guidelines for the use of antiretroviral agents in adults and adolescents with HIV[Internet]. U.S. National Library of Medicine. 2018 [cited 2019 Aug 22]. Available from:https:\/\/aidsinfo.nih.gov\/guidelines\/html\/1\/adult\u2010and\u2010adolescent\u2010arv\/11\/what\u2010to\u2010start"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.13155","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:37:30Z","timestamp":1692877050000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/hiv.13155"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13155","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,25]]},"assertion":[{"value":"2021-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}