{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T02:38:53Z","timestamp":1769999933857,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Polypharmacy in people living with HIV (PLWH) increases the risks of medicine\u2010related problems (events or circumstances involving drug therapy that actually or potentially interfere with desired health outcomes). We aimed to examine the feasibility and acceptability of a Medicines Management Optimisation Review (MOR) toolkit in HIV outpatients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multi\u2010centre randomized controlled study across four HIV centres. In all, 200 PLWH on combination antiretroviral therapy, either &gt;\u00a050\u00a0years old or &lt;\u00a050\u00a0years with other comorbidities, were enrolled to have a MOR or received standard pharmaceutical care. The primary outcome was the difference in the number of medicine\u2010related problems (MRPs) between intervention and standard care groups at baseline and 6\u00a0months. Acceptability, cost of the intervention and health\u2010related quality of life were also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 164 patients were analysed: 70 in the intervention group and 94 in the standard care group. A significant number of MRPs were detected in those patients receiving MOR compared with the standard care group at baseline (93 vs. 2; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, <jats:italic>z<\/jats:italic>\u00a0=\u00a0\u22128.6, <jats:italic>r<\/jats:italic> = 0.6) and 6\u00a0months (33 vs. 3; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, <jats:italic>z<\/jats:italic>\u00a0=\u00a0\u22125.7, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.4). A significant reduction in the number of new MRPs at 6\u00a0months in the intervention group versus baseline was also observed (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001, <jats:italic>Z<\/jats:italic>\u00a0=\u00a0\u22123.7, <jats:italic>r<\/jats:italic> = 0.2); 44% of MRPs were fully resolved at baseline and 51% at 6\u00a0months. No changes in health\u2010related quality of life following MOR or between MOR and standard care groups were observed. The MORs were highly acceptable among patients and healthcare professionals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The MOR toolkit was feasible and acceptable, suggesting that HIV outpatient services might consider implementing MOR for targeted populations under their care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13158","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T16:12:14Z","timestamp":1630512734000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structured medicines reviews in HIV outpatients: a feasibility study (The MOR Study)"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-0685","authenticated-orcid":false,"given":"Heather A.","family":"Leake Date","sequence":"first","affiliation":[{"name":"University Hospitals Sussex NHS Foundation Trust, Royal Sussex County Hospital  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Alford","sequence":"additional","affiliation":[{"name":"University Hospitals Sussex NHS Foundation Trust, Royal Sussex County Hospital  Brighton UK"},{"name":"Department of Global Health and Infection Brighton and Sussex Medical School  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Hounsome","sequence":"additional","affiliation":[{"name":"Department of Global Health and Infection Brighton and Sussex Medical School  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Moore","sequence":"additional","affiliation":[{"name":"University Hospitals Sussex NHS Foundation Trust, Western Sussex Hospital  Worthing UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kin","family":"Ing","sequence":"additional","affiliation":[{"name":"University Hospitals Sussex NHS Foundation Trust, Western Sussex Hospital  Worthing UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1165-0573","authenticated-orcid":false,"given":"Jaime H.","family":"Vera","sequence":"additional","affiliation":[{"name":"University Hospitals Sussex NHS Foundation Trust, Royal Sussex County Hospital  Brighton UK"},{"name":"Department of Global Health and Infection Brighton and Sussex Medical School  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010018\u20106118\u2010x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.02.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25449"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/652149"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr248"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1482"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2013.851006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3293"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4928"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1540"},{"key":"e_1_2_9_12_1","unstructured":"WHO.Medication without harm \u2010 global patient safety challenge on medication safety.World Health Organization 2017 Licence: CCBY\u2010NC\u2010SA30IGO.2017."},{"key":"e_1_2_9_13_1","unstructured":"NICE. 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