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Some of the highest incidence rates for HIV and the highest proportion of multi\u2010drug\u2010resistant (MDR) tuberculosis worldwide are found in the region. The purpose of this article is to review the challenges and important next steps to improve healthcare for people living with TB, HIV and hepatitis C (HCV) in eastern Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>References for this narrative review were identified through systematic searches of PubMed using pre\u2010idientified key word for articles published in English from January 2000 to August 2020. After screening of titles and abstracts 37 articles were identified as relevant for this review. Thirty\u2010eight further articles and sources were identified through searches in the authors\u2019 personal files and in Google Scholar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Up to 50% of HIV\/MDR\u2010TB\u2010coinfected individuals in the region die within 2 years of treatment initiation. Antiretroviral therapy (ART) coverage for people living with HIV (PLHIV) and the proportion virological suppressed are far below the UNAIDS 90% targets. In theory, access to various diagnostic tests and treatment of drug\u2010resistant TB exists, but real\u2010life data point towards inadequate testing and treatment. New treatments could provide elimination of viral HCV in high\u2010risk populations but few countries have national programmes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Some eastern European countries face serious challenges to achieve the sustainable development goal\u2010related target of 3.3 by 2030, among others, to end the epidemics of AIDS and tuberculosis. Better integration of healthcare systems, standardization of health care, unrestricted substitution therapy for all people who inject drugs, widespread access to drug susceptibility testing, affordable medicines and a sufficiently sized, well\u2010trained health workforce could address some of those challenges.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13163","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T10:55:44Z","timestamp":1630493744000},"page":"48-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Improving healthcare for patients with HIV, tuberculosis and hepatitis C in eastern Europe: a review of current challenges and important next steps"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5224-0335","authenticated-orcid":false,"given":"Christian","family":"Kraef","sequence":"first","affiliation":[{"name":"CHIP (Centre of Excellence for Health, Immunity and Infections) Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Infectious Disease, Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Heidelberg Institute of Global Health University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5438-1513","authenticated-orcid":false,"given":"Adrian","family":"Bentzon","sequence":"additional","affiliation":[{"name":"CHIP (Centre of Excellence for Health, Immunity and Infections) Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Skrahina","sequence":"additional","affiliation":[{"name":"Republican Scientific and Practical Center for Pulmonology and Tuberculosis Minsk Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Mocroft","sequence":"additional","affiliation":[{"name":"CHIP (Centre of Excellence for Health, Immunity and Infections) Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Centre for Clinical Research, Epidemiology, Modelling and Evaluation (CREME) Institute for Global Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Peters","sequence":"additional","affiliation":[{"name":"CHIP (Centre of Excellence for Health, Immunity and Infections) Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens D.","family":"Lundgren","sequence":"additional","affiliation":[{"name":"CHIP (Centre of Excellence for Health, Immunity and Infections) Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Infectious Disease, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-825X","authenticated-orcid":false,"given":"Nikoloz","family":"Chkhartishvili","sequence":"additional","affiliation":[{"name":"Infectious Diseases AIDS &amp; Clinical Immunology Research Center Tbilisi Georgia"},{"name":"Caucasus International University Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-0597","authenticated-orcid":false,"given":"Daria","family":"Podlekareva","sequence":"additional","affiliation":[{"name":"CHIP (Centre of Excellence for Health, Immunity and Infections) Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Infectious Disease, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Kirk","sequence":"additional","affiliation":[{"name":"CHIP (Centre of Excellence for Health, Immunity and Infections) Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Infectious Disease, Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"HIV\/AIDS [Internet]. 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