{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:31:43Z","timestamp":1784043103553,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Tuberculosis symptoms are very common among people living with HIV (PLHIV) initiating antiretroviral therapy (ART), are not specific for tuberculosis disease and may result in delayed ART start. The risks and benefits of same\u2010day ART initiation in PLHIV with tuberculosis symptoms are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically reviewed nine databases on 12\u00a0March 2020 to identify studies that investigated same\u2010day ART initiation among PLHIV with tuberculosis symptoms and reported both their approach to TB screening and clinical outcomes. We extracted and summarized data about TB screening, numbers of people starting same\u2010day ART and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included four studies. Two studies deferred ART for everyone with any tuberculosis symptoms (one or more of cough, fever, night sweats or weight loss) and substantial numbers of people had deferred ART start (28% and 39% did not start same\u2010day ART). Two studies permitted some people with tuberculosis symptoms to start same\u2010day ART, and fewer people deferred ART (2% and 16% did not start same\u2010day). Two of the four studies were conducted sequentially; proven viral load suppression at 8 months was 31% when everyone with tuberculosis symptoms had ART deferred, and 44% when the algorithm was changed so that some people with tuberculosis symptoms could start same\u2010day ART.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although tuberculosis symptoms are very common in people starting ART, there is insufficient evidence about whether presence of tuberculosis symptoms should lead to ART start being deferred or not. Research to inform clear guidelines would help to maximise the benefits of same\u2010day ART.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13169","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T04:14:18Z","timestamp":1631765658000},"page":"4-15","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Same\u2010day antiretroviral therapy initiation for people living with HIV who have tuberculosis symptoms: a systematic review"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-5030","authenticated-orcid":false,"given":"Rachael M.","family":"Burke","sequence":"first","affiliation":[{"name":"Clinical Research Department Faculty of Infectious and Tropical Disease London School of Hygiene and Tropical Medicine  London UK"},{"name":"Malawi\u2010Liverpool\u2010Wellcome Clinical Research Programme  Blantyre Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah M.","family":"Rickman","sequence":"additional","affiliation":[{"name":"Clinical Research Department Faculty of Infectious and Tropical Disease London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vindi","family":"Singh","sequence":"additional","affiliation":[{"name":"WHO Global HIV Hepatitis and STI Programme  Geneva Switzerland"},{"name":"Global Fund to fight AIDS Tuberculosis and Malaria  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thokozani","family":"Kalua","sequence":"additional","affiliation":[{"name":"Department of HIV and AIDS Ministry of Health Government of Malawi  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklaus D.","family":"Labhardt","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute  Basel Switzerland"},{"name":"University of Basel"},{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Hosseinipour","sequence":"additional","affiliation":[{"name":"University North Carolina  USA"},{"name":"UNC Project  Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Imperial College London  UK"},{"name":"Wellcome Centre for Infectious Diseases Research in Africa and Institute of Infectious Disease and Molecular Medicine University of Cape Town  Rondebosch South Africa"},{"name":"Francis Crick Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"MacPherson","sequence":"additional","affiliation":[{"name":"Clinical Research Department Faculty of Infectious and Tropical Disease London School of Hygiene and Tropical Medicine  London UK"},{"name":"Malawi\u2010Liverpool\u2010Wellcome Clinical Research Programme  Blantyre Malawi"},{"name":"Liverpool School of Tropical Medicine  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506816"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001671"},{"key":"e_1_2_10_4_1","unstructured":"WHO | Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy [Internet]. WHO. Cited September 10 2019.http:\/\/www.who.int\/hiv\/pub\/guidelines\/advanced\u2010HIV\u2010disease\/en\/"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000802"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1141"},{"key":"e_1_2_10_7_1","unstructured":"WHO.Updated recommendations on HIV prevention infant diagnosis antiretroviral initiation and monitoring [Internet]. World Health Organization; 2021. Cited April 15 2021.https:\/\/apps.who.int\/iris\/handle\/10665\/340190"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30137-1"},{"key":"e_1_2_10_9_1","first-page":"355","article-title":"ROBINS\u2010I: a tool for assessing risk of bias in non\u2010randomised studies of interventions","author":"Sterne JA","year":"2016","journal-title":"BMJ [Internet]."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002015"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.1818"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002912"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003226"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4102\/sajhivmed.v16i1.367"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001874"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209477"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30148-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3054"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","unstructured":"MacKellarD. Peer\u2010Delivered Linkage Case Management and Same\u2010Day ART Initiation for Men and Young Persons with HIV Infection \u2014 Eswatini 2015\u20132017. MMWR Morb Mortal Wkly Rep [Internet]. 2018 [cited 2020 Jul 3];67. Available from:https:\/\/www.cdc.gov\/mmwr\/volumes\/67\/wr\/mm6723a3.htm","DOI":"10.15585\/mmwr.mm6723a3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25108"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5588\/pha.18.0030"},{"key":"e_1_2_10_22_1","unstructured":"SeekaewP TeeratakulpisarnN SurapuchongP TeeratakulpisarnS AmataveteS JomjaP et al.Same\u2010day ART initiation in HIV\/STI testing center in Bangkok Thailand: Initial results from an implementation research. Journal of the International AIDS Society Conference: 22nd International AIDS Conference AIDS [Internet].2018;21.http:\/\/programme.aids2018.org\/Abstract\/Abstract\/5201"},{"key":"e_1_2_10_23_1","unstructured":"SeekaewP AmataveteS TeeratakulpisarnN LeenasirimakulP KhusuwanS MathajittiphanP et al.Same\u2010day antiretroviral therapy initiation in Thailand: Different models and initial outcomes from scale\u2010up in five provinces in Thailand. Journal of the International AIDS Society Conference: 10th IAS Conference on HIV Science Mexico [Internet].2019;22.http:\/\/programme.ias2019.org\/Abstract\/Abstract\/2778"},{"key":"e_1_2_10_24_1","unstructured":"SeekaewP SongtaweesinWN PuthanakitT AmataveteS TeeratakulpisarnN SurapuchongP et al.High acceptability and feasibility of same\u2010day antiretroviral therapy services among HIV\u2010positive adolescents in Bangkok Thailand. Journal of the International AIDS Society Conference: 10th IAS Conference on HIV Science Mexico [Internet].2019;22.http:\/\/programme.ias2019.org\/Abstract\/Abstract\/2740"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25458"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227572"},{"key":"e_1_2_10_27_1","first-page":"14","article-title":"Toward universal HIV treatment in Haiti: time trends in ART retention following expanded ART eligibility in a national cohort from 2011\u201317","volume":"14","author":"Puttkammer N","year":"2020","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.6565"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2012.668173"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.20672"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.20662"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-018-5258-3"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25133"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002027"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001134"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002124"},{"key":"e_1_2_10_37_1","first-page":"512s","article-title":"Getting a jump on HIV: expedited ARV treatment at NYC sexual health clinics, 2017","volume":"26","author":"Blank S","year":"2018","journal-title":"Top Antivir Med."},{"key":"e_1_2_10_38_1","first-page":"S8","article-title":"Jumpstart is a head start: Initiating antiretroviral treatment on day of HIV diagnosis in New York city health department sexual health clinics, 2016\u20132017","volume":"45","author":"Pathela P","year":"2018","journal-title":"Sex Transm Dis"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz161"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010033246"},{"key":"e_1_2_10_41_1","first-page":"S478","article-title":"Successful intervention to reduce the time interval between diagnosis and viral load suppression in patients living with HIV in the Midwestern United States","volume":"6","author":"Ilagan D","year":"2019","journal-title":"Open Forum Infect Dis."},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-019-02655-w"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12780"},{"key":"e_1_2_10_44_1","unstructured":"WHO.Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection Recommendations for a public health approach \u2010 Second edition.2016."},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002357"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2979"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1139"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1402"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1824"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910708"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.13169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:38:17Z","timestamp":1692877097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/hiv.13169"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13169","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"2021-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}