{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:43:34Z","timestamp":1790628214918,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Current British HIV Association (BHIVA) guidelines recommend the use of FRAX for the routine assessment of bone fracture risk in people living with HIV over 50\u00a0years of age every 3\u00a0years. Bone mineral density measurement with dual\u2010energy X\u2010ray absorptiometry (DXA) scan is recommended for those with increased fracture risk (FRAX major &gt;\u00a010%). Our objectives were to estimate the prevalence of and risk factors for osteoporosis in a population of PLWH aged\u00a0&gt;\u00a050\u00a0years and assess the utility of FRAX in predicting the presence of DXA\u2010proven osteoporosis in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study of a cohort of PLWH aged &gt;\u00a050\u00a0years attending the Chelsea and Westminster Hospital and who had a DXA scan between January 2009 and December 2018. FRAX scores were calculated using the Sheffield algorithm. Multiple regression models and Cohen's kappa values were used to assess risk factors for osteoporosis and agreement between FRAX and DXA scan results, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 744 patients were included (92.9% male, mean age 56\u00a0\u00b1\u00a05\u00a0years). The prevalence rates of osteoporosis (at DXA scans) and osteopenia were 12.2% and 63.7%, respectively. FRAX major was &gt;\u00a010% in only two patients, while 90\/91 (98.9%) patients with osteoporosis had a normal FRAX score. The presence of osteoporosis was significantly associated with low body mass index and estimated glomerular filtration rate (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that FRAX scores did not predict the presence of osteoporosis in our population of PLWH over 50\u00a0years of age and therefore FRAX scores may not be the appropriate tool to define eligibility to perform DXA scans in PLWH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13170","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T02:12:48Z","timestamp":1632103968000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["FRAX assessment in people ageing with HIV"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0263-0703","authenticated-orcid":false,"given":"Maria","family":"Mazzitelli","sequence":"first","affiliation":[{"name":"Research and Development Department Chelsea and Westminster Hospital  London UK"},{"name":"Medical and Surgical Sciences Department \u201cMagna Graecia\u201d University  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pereira","family":"Branca Isabel","sequence":"additional","affiliation":[{"name":"Research and Development Department Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Tokyo Medical University Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimie","family":"Chirwa","sequence":"additional","affiliation":[{"name":"Research and Development Department Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundhiya","family":"Mandalia","sequence":"additional","affiliation":[{"name":"Research and Development Department Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Moyle","sequence":"additional","affiliation":[{"name":"Research and Development Department Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boffito","family":"Marta","sequence":"additional","affiliation":[{"name":"Research and Development Department Chelsea and Westminster Hospital  London UK"},{"name":"Division of Infectious Diseases Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Milinkovic","sequence":"additional","affiliation":[{"name":"Research and Development Department Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328334fe9a"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2979"},{"key":"e_1_2_8_4_1","first-page":"164","article-title":"Osteoporosis and the burden of osteoporosis\u2010related fractures","volume":"17","author":"Dempster DW","year":"2011","journal-title":"Am J Manag Care"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.4349"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-010-0060-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq158"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-011-0099-z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004497"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2013.0252"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/656417"},{"key":"e_1_2_8_12_1","article-title":"BHIVA guidelines for the routine investigation and monitoring of adult HIV\u20101 positive individuals (2019 interim update)","author":"Angus B","year":"2019","journal-title":"BHIVA"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12878"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-010-0032-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2012.011412"},{"key":"e_1_2_8_16_1","unstructured":"FRAX\u00ae calculator. Accessed May 15 2021. https:\/\/www.sheffield.ac.uk\/FRAX\/index.aspx?lang=it"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4134"},{"key":"e_1_2_8_18_1","unstructured":"WHO Scientific Group on the Prevention and Management of Osteoporosis.Prevention and management of osteoporosis: report of a WHO scientific group. 2000;7:31.17."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-018-1874-2"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32801022eb"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233501"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2014.0205"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/656412"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-014-9911-2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.248"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.13170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T11:37:47Z","timestamp":1692877067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,19]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/hiv.13170"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13170","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,19]]},"assertion":[{"value":"2021-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}