{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:11:41Z","timestamp":1761419501187,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Integrase strand transfer inhibitors (INSTIs) are commonplace in modern antiretroviral therapy (ART). Increased weight gain with their use is increasingly scrutinized. We evaluated weight changes in treatment\u2010na\u00efve adults with HIV\u20101 attending a UK centre who started regimens including raltegravir or dolutegravir.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of adults prescribed an INSTI between January 2015 and March 2020 were categorized as having started an ART regimen containing raltegravir, dolutegravir, a protease inhibitor or a nonnucleoside reverse transcriptase inhibitor. Individuals with one or more weight measurement \u2264\u00a05\u00a0years both pre\u2010 and post\u2010ART initiation, who started a three\u2010drug regimen with \u2265\u00a06\u00a0months duration and achieved virological suppression (&lt;\u00a050 copies\/mL) within 6\u00a0months were included. A random effects model with linear slope pre\u2010 and post\u2010ART was used, adjusting for age, gender, ethnicity, ART regimen, backbone and year of initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort included 390 adults; 88.7% were male, 66.4% were of white ethnicity, their median age was 40\u00a0years, there was a median of six weight measurements, 2.2\u00a0years from diagnosis to ART initiation, 2.9\u00a0years from ART to the last weight measurement, and weight and body mass index at initiation were 75 kg and 24.1 kg\/m<jats:sup>2<\/jats:sup> respectively. Of these, 254 (65%) started an INSTI. The average pre\u2010ART rate of weight gain was 0.44 kg\/year [95% confidence interval (CI): 0.19\u20130.70], increasing to 0.88 kg\/year (0.63\u20131.10, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.04) after ART initiation. Our adjusted model found no evidence of an association between ART regimen and rate of weight gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Weight increased in the cohort both pre\u2010 and post\u2010ART. We found no evidence of a higher rate of weight gain following ART initiation with an INSTI compared with other regimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13186","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T03:19:32Z","timestamp":1634267972000},"page":"294-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["No overall impact on rate of weight gain with integrase inhibitor\u2010containing regimens in antiretroviral\u2010na\u00efve adults"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3282-4998","authenticated-orcid":false,"given":"James E.","family":"Burns","sequence":"first","affiliation":[{"name":"Centre for Clinical Research in Infection and Sexual Health Institute for Global Health University College London  London UK"},{"name":"Central and North West London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8705-3281","authenticated-orcid":false,"given":"Oliver","family":"Stirrup","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research in Infection and Sexual Health Institute for Global Health University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1379-1775","authenticated-orcid":false,"given":"Laura","family":"Waters","sequence":"additional","affiliation":[{"name":"Central and North West London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Dunn","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research in Infection and Sexual Health Institute for Global Health University College London  London UK"},{"name":"Medical Research Council Clinical Trials Unit Institute of Clinical Trials and Methodology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Gilson","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research in Infection and Sexual Health Institute for Global Health University College London  London UK"},{"name":"Central and North West London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L.","family":"Pett","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research in Infection and Sexual Health Institute for Global Health University College London  London UK"},{"name":"Central and North West London NHS Foundation Trust  London UK"},{"name":"Medical Research Council Clinical Trials Unit Institute of Clinical Trials and Methodology University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"European AIDS Clinical Society.EACS Guidelines version 10.1.2020."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002603"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw096"},{"key":"e_1_2_10_5_1","unstructured":"PinheiroJBD DebRoyS SarkarD R Core Team.nlme: Linear and Nonlinear Mixed Effects Models. R package. 3.1\u2010151 ed2020."},{"volume-title":"R: A language and environment for statistical computing","year":"2013","author":"R Core Team","key":"e_1_2_10_6_1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz999"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30241-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002379"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30277-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014296"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980021000768"},{"issue":"9","key":"e_1_2_10_13_1","first-page":"645","article-title":"Weight evolution and perceptions of adults living with HIV following initiation of antiretroviral therapy in a South African urban setting","volume":"101","author":"Hurley E","year":"2011","journal-title":"S Afr Med J"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14177"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002725"},{"key":"e_1_2_10_16_1","unstructured":"NHS Digital.Health Survey for England 2019: Overweight and obesity in adults and children.2020."},{"key":"e_1_2_10_17_1","unstructured":"HalesCM CarrollMD FryarCD OgdenCL.Prevalence of obesity and severe obesity among adults: United States 2017\u20132018. National Center for Health Statistics. 2020."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30077-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2016.05.011"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-014-0530-4"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.2"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.13186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T19:35:43Z","timestamp":1692992143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,11]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/hiv.13186"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13186","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"type":"print","value":"1464-2662"},{"type":"electronic","value":"1468-1293"}],"subject":[],"published":{"date-parts":[[2021,10,11]]},"assertion":[{"value":"2021-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}