{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:43:33Z","timestamp":1790477013694,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A standardized non\u2010occupational post\u2010exposure prophylaxis (nPEP) programme was implemented to improve guideline compliance for treatment of post\u2010sexual assault patients within an emergency department (ED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre, retrospective, observational study of adult patients evaluated in the ED for sexual assault was performed following nPEP programme implementation. A comprehensive nPEP programme consisting of a standardized order set, real\u2010time multidisciplinary consultation, on\u2010site pharmacy and close post\u2010discharge follow\u2010up was implemented between July 2017 and June 2018. Laboratory, treatment, vaccination, prescription and follow\u2010up data during the pre\u2010 (July 2016 to June 2017) and post\u2010intervention (July 2018 to August 2019) periods were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 147 post\u2010sexual assault patients included in this study (59 pre\u2010intervention, 88 post\u2010intervention), 133 (90.5%) were eligible for nPEP. Patient demographics and rate of those eligible for nPEP were similar in both cohorts. Antiretroviral therapy (ART) was offered (72.2% vs. 100%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005) and ultimately prescribed (51.9% vs. 86.1%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005) more frequently following nPEP programme implementation. Patients were more likely to have appropriate screening for renal function, liver function, pregnancy, syphilis, hepatitis B, hepatitis C and HIV in the post\u2010intervention period (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005). Hepatitis B vaccination was more commonly administered post\u2010intervention (8.5% vs. 22.7%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.024). In\u2010person 28\u2010day follow\u2010up was rare in both pre\u2010 (3.5%) and post\u2010intervention (11.3%) cohorts (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.278).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Implementation of a comprehensive nPEP programme resulted in improved guideline compliance with more frequent and appropriate ART administration. Recommended screening laboratories and hepatitis B vaccinations were more commonly performed, but in\u2010person follow\u2010up remained low. The nPEP programmes should be implemented to standardize efforts that decrease the risk of HIV transmission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13196","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T07:26:21Z","timestamp":1635837981000},"page":"268-273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Standardizing HIV post\u2010exposure prophylaxis in the emergency department following sexual assault"],"prefix":"10.1111","volume":"23","author":[{"given":"Jennifer","family":"Silva\u2010Nash","sequence":"first","affiliation":[{"name":"College of Medicine University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacie","family":"Bordelon","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrie A.","family":"Searcy","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9540-2683","authenticated-orcid":false,"given":"Ryan K.","family":"Dare","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"e_1_2_8_2_1","article-title":"HIV transmission | HIV basics | HIV\/AIDS | CDC","author":"CDC","year":"2019","journal-title":"Centers Dis Control Prev"},{"key":"e_1_2_8_3_1","unstructured":"DominguezKL SmithDK ThomasV et al.Updated guidelines for antiretroviral postexposure prophylaxis after sexual injection drug use or other nonoccupational exposure to HIV\u2014United States 2016.https:\/\/stacks.cdc.gov\/view\/cdc\/38856. Accessed April 15 2021."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2007.0157"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/196963"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2017.04.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3100"},{"key":"e_1_2_8_8_1","first-page":"204","article-title":"Prophylaxis provided to sexual assault victims seen at US emergency departments","volume":"57","author":"Rovi S","year":"2002","journal-title":"J Am Med Womens Assoc"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060346"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/760706"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2093"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540120020014228"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqv053"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12797"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_8_16_1","first-page":"1","article-title":"Antiretroviral postexposure prophylaxis after sexual, injection\u2010drug use, or other nonoccupational exposure to HIV in the United States: recommendations from the U.S. Department of Health and Human Services","volume":"54","author":"Smith DK","year":"2005","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-019-02545-1"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.13196","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T19:34:50Z","timestamp":1692992090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,2]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/hiv.13196"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13196","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,2]]},"assertion":[{"value":"2021-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}