{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:56:20Z","timestamp":1785390980357,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Although the risk of AIDS\u2010associated diseases has declined dramatically with combination antiretroviral therapy (cART), the incidence rates of chronic non\u2010AIDS\u2010associated diseases in perinatally HIV\u2010infected adults have risen and have not been well characterized. Both traditional and HIV\u2010associated risk factors have been found to contribute to hypertension in non\u2010perinatally HIV\u2010infected adults; whether these same factors contribute to hypertension in perinatally infected adults is not known. The purpose of this study was to determine the socio\u2010demographic, clinical, virological and immunological factors associated with systemic hypertension among a cohort of perinatally HIV\u2010infected adolescents and young adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a case\u2013control study among a population of adults aged 18\u201335\u00a0years with perinatally acquired HIV infection receiving care at the University of Maryland Medical Center. Covariates assessed included traditional risk factors such as age, family history of hypertension, and smoking, as well as numerous HIV\u2010 and antiretroviral\u2010associated covariates, including CD4 nadir.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Approximately 31% of the cohort met criteria for hypertension. There were no significant differences in the odds of most traditional or HIV\u2010associated risk factors among perinatally HIV\u2010infected adults with hypertension compared with those with no diagnosis of hypertension. Exposure to lopinavir\/ritonavir was associated with greater odds of not having hypertension, while a concurrent diagnosis of chronic kidney disease (CKD) was associated with greater odds of having hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study suggest that most traditional and HIV\u2010related risk factors do not appear to increase the odds of having hypertension in this cohort of individuals. The aetiology of hypertension in this population remains to be elucidated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13199","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T07:18:51Z","timestamp":1635837531000},"page":"457-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing risk factors for hypertension in young adults with perinatally acquired HIV infection: A case\u2013control study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9619-0739","authenticated-orcid":false,"given":"Patrick J.","family":"O\u2019Neil","sequence":"first","affiliation":[{"name":"Greater Lawrence Family Health Center  Lawrence Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-6436","authenticated-orcid":false,"given":"Kristen A.","family":"Stafford","sequence":"additional","affiliation":[{"name":"Institute of Human Virology University of Maryland Medical School  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-021X","authenticated-orcid":false,"given":"Patrick A.","family":"Ryscavage","sequence":"additional","affiliation":[{"name":"Institute of Human Virology University of Maryland Medical School  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61809-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/652283"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-011-0073-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325957416668034"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.14423\/SMJ.0000000000001001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt182"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32830ef5fb"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325957413491432"},{"issue":"3","key":"e_1_2_7_10_1","article-title":"Risk factors related to hypertension among patients in a cohort living with HIV\/AIDS","volume":"14","author":"Roque de Arruda E","year":"2010","journal-title":"Brazil J Infect Dis"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000171410.76607.f8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v6n2p58"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.05.016"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1310\/5E7Q-PGWB-16UE-J48U"},{"issue":"7","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1177\/135965350501000706","article-title":"Predictors of hypertension and changes of blood pressure in HIV\u2010infected patient","volume":"10","author":"Thi\u00e9baut R","year":"2005","journal-title":"Antivir Ther"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00699.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08468-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200305230-00010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000168"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2010.02.009"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.081760"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2333794X15625159"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3182a9466a"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1437"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-014-2809-x"},{"issue":"35","key":"e_1_2_7_26_1","first-page":"703","article-title":"Vital signs: awareness and treatment of uncontrolled hypertension among adults \u2014 United States, 2003\u20132010","volume":"61","author":"Centers for Disease Control and Prevention","year":"2012","journal-title":"MMWR"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/621565"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31821c79d2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.117333"},{"key":"e_1_2_7_30_1","unstructured":"Behavioral Risk Factor Surveillance System (BRSS).Hypertension Awareness: Adults who have been told they have high blood pressure.2005. 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