{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:35:54Z","timestamp":1792449354994,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Comorbidities are associated with a high burden of disease in people living with HIV (PLWH). The objective was to investigate the prevalence of chronic comorbidities and use of co\u2010medications in PLWH in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study retrospectively analysed clinical information from PLWH receiving antiretroviral therapy (ART) between April 2009 and March 2019. Demographic characteristics, numbers and types of chronic comorbidities, and numbers and types of non\u2010ART co\u2010medications, were described by age groups. The source of data was the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 28\u00a0089 PLWH (male 91.9%) who used ART were identified. Out of 28\u00a0089 PLWH, 81.5% had at least one chronic comorbidity. The numbers of AIDS\u2010defining cancers and non\u2010AIDS\u2010defining cancers in this Japanese cohort were 2432 (8.7%) and 2485 (8.8%), respectively. The cumulative burden of comorbidities including non\u2010AIDS\u2010defining cancer increased with age. Changes in trend between 2009 and 2019 were observed, including a higher proportion of PLWH diagnosed at \u2265\u00a070\u00a0years old [2019 (4.7%) vs. 2009 (2.4%)] and a decreasing percentage of patients with AIDS\u2010defining cancers (down from 6.3% to 4.8% between 2009 and 2019). The most common co\u2010medications during the most recent 3\u2010month period were lipid\u2010regulating\/anti\u2010atheroma preparations (11.3%), antacids, antiflatulents and anti\u2010ulcerants (9.6%), and agents acting on the renin\u2013angiotensin system (8.1%). The three most common therapeutic categories of co\u2010medications during the study period were antacids, antiflatulents and anti\u2010ulcerants (35.0%), systemic antihistamines (33.7%) and psycholeptics (27.1%). More than 30% of PLWH aged &gt;\u00a040\u00a0years used at least one co\u2010medication in a 3\u2010month period, while more than half of PLWH aged &gt;\u00a030\u00a0years had at least one co\u2010medication prescribed concomitantly for a total of \u2265\u00a090\u00a0days during the study period, and the numbers of co\u2010medications used were greater in the older age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The burden of chronic comorbidities and co\u2010medication were found to be greater in older, as compared to younger patients, among 28\u00a0089 PLWH in a nationwide study in Japan. This finding suggests the need to identify elderly PLWH and to appropriately manage their HIV and comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13206","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T09:35:41Z","timestamp":1637919341000},"page":"485-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Comorbidities and co\u2010medications among 28\u00a0089 people living with HIV: A nationwide cohort study from 2009 to 2019 in Japan"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-9930","authenticated-orcid":false,"given":"Toshio","family":"Naito","sequence":"first","affiliation":[{"name":"Department of General Medicine Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of 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