{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:10:10Z","timestamp":1771539010277,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this international multicentre study was to review potential drug\u2013drug interactions (DDIs) for real\u2010life coadministration of combination antiretroviral therapy (cART) and coronavirus disease 2019 (COVID\u201019)\u2010specific medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Euroguidelines in Central and Eastern Europe Network Group initiated a retrospective, observational cohort study of HIV\u2010positive patients diagnosed with severe acute respiratory syndrome\u00a0coronavirus 2 (SARS\u2010CoV\u20102) infection. Data were collected through a standardized questionnaire and DDIs were identified using the University of Liverpool's interaction checker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 524 (94.1% of 557) patients received cART at COVID\u201019 onset: 117 (22.3%) were female, and the median age was 42 (interquartile range 36\u201350) years. Only 115 (21.9%) patients were hospitalized, of whom 34 required oxygen therapy. The most frequent nucleoside reverse transcriptase inhibitor (NRTI) backbone was tenofovir disoproxil fumarate (TDF)\/tenofovir alafenamide (TAF) with lamivudine or emtricitabine (XTC) (79.3%) along with an integrase strand transfer inhibitor (INSTI) (68.5%), nonnucleoside reverse transcriptase inhibitor (NNRTI) (17.7%), protease inhibitor (PI) (13.7%) or other (2.5%). In total, 148 (28.2%) patients received COVID\u201019\u2010specific treatments: corticosteroids (15.7%), favipiravir (7.1%), remdesivir (3.1%), hydroxychloroquine (2.7%), tocilizumab (0.6%) and anakinra (0.2%). In total, 62 DDI episodes were identified in 58 patients (11.8% of the total cohort and 41.9% of the COVID\u201019\u2010specific treatment group). The use of boosted PIs and elvitegravir accounted for 43 DDIs (29%), whereas NNRTIs were responsible for 14 DDIs (9.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this analysis from the Central and Eastern European region on HIV\u2010positive persons receiving COVID\u201019\u2010specific treatment, it was found that potential DDIs were common. Although low\u2010dose steroids are mainly used for COVID\u201019 treatment, comedication with boosted antiretrovirals seems to have the most frequent potential for DDIs. In addition, attention should be paid to NNRTI coadministration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13214","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T08:38:45Z","timestamp":1638520725000},"page":"693-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Retrospective evaluation of an observational cohort by the Central and Eastern Europe Network Group shows a high frequency of potential drug\u2013drug interactions among HIV\u2010positive patients receiving treatment for coronavirus disease 2019\u00a0(COVID\u201019)"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-7639","authenticated-orcid":false,"given":"Botond","family":"Lakatos","sequence":"first","affiliation":[{"name":"HIV Center National Institute of Hematology and Infectious Diseases South Pest Central Hospital  Budapest 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Zagreb  Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Vassilenko","sequence":"additional","affiliation":[{"name":"Global Fund Grant Management Department Republican Scientific and Practical Center for Medical Technologies  Minsk Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Wasilewski","sequence":"additional","affiliation":[{"name":"4th Department Hospital for Infectious Diseases in Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Fleischhans","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases 1st Faculty of Medicine Charles University in Prague and Faculty Hospital Bulovka  Bulovka Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Jilich","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases 1st Faculty of Medicine Charles University 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