{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:24:04Z","timestamp":1780622644829,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to analyze the incidence rates of new\u2010onset diabetes, hypertriglyceridemia, hypercholesterolemia, liver injury, and renal injury during antiretroviral therapy (ART) among people living with HIV (PLWH) and determine the associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included PLWH enrolled from Beijing Ditan Hospital from November 11, 2004, to December 29, 2018. The incidence rates of new\u2010onset diabetes, hypertriglyceridemia, hypercholesterolemia, liver injury, and renal injury were calculated and stratified based on ART regimen, CD4 count, and HIV\u2010RNA. Risk factors were determined using Cox regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 6747 participants were included. Moreover, 4.5%, 43.3%, 25.4%, 11.2%, and 6.2% of patients developed new\u2010onset diabetes, hypertriglyceridemia, hypercholesterolemia, liver injury, and renal injury, respectively, with incidence rates of 1.7, 26.9, 10.2, 3.9, and 5.5 per 100 person\u2010years, respectively. Longitudinally, the incidence rates and percentages of these outcomes were highest in the first year of ART. The percentage of dyslipidemia was significantly higher in protease inhibitor (PI)\u2010based regimen than in non\u2010nucleoside reverse transcriptase inhibitor (NNRTI)\u2010based regimen. However, the percentage of liver injury was significantly higher in NNRTI\u2010based regimen than in PI\u2010based regimen. In multivariate Cox regression analysis, low CD4 count (&lt;200 cells\/\u00b5L, adjusted hazard ratio [aHR]\u00a0=\u00a01.34, 95% confidence interval [CI] 1.15\u20131.57) and high HIV\u2010RNA (&gt;10<jats:sup>5<\/jats:sup> copies\/mL, aHR\u00a0=\u00a01.26, 95% CI 1.08\u20131.48) were risk factors for hypertriglyceridemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical outcomes, including new\u2010onset diabetes, dyslipidemia, and liver and renal injuries, are common in PLWH. Regular glucose, lipid, liver, and renal function monitoring is required during ART, especially in high\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13247","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T01:39:48Z","timestamp":1647394788000},"page":"32-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Longitudinal analysis of new\u2010onset non\u2010AIDS\u2010defining diseases among people living with HIV: A real\u2010world observational study"],"prefix":"10.1111","volume":"23","author":[{"given":"Yujiao","family":"Duan","sequence":"first","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University  Beijing China"},{"name":"Clinical Center for HIV\/AIDS Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Ditan 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