{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:43:59Z","timestamp":1771274639171,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000864","name":"British HIV Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Current UK guidelines for cervical cancer screening are based on the assumption that most women living with HIV (WLWH) are also high\u2010risk (HR) human papillomavirus (HPV)\u2010positive. We aimed to provide data on prevalence of HR\u2010HPV in WLWH in the UK and to assess feasibility and acceptability of HR\u2010HPV self\u2010sampling in this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women living with HIV attending six HIV services in London\/south of England, with no history of cervical cancer, were enrolled. Participants self\u2010collected a vaginal swab for the detection of HR\u2010HPV, completed a survey about sexual\/gynaecological history, attitudes towards annual screening and perception of HR\u2010HPV self\u2010sampling, and were asked to have their annual cervical smear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 67 women were included: 86.5% were of black ethnicity, the median (range) age was 47 (24\u201360) years, median CD4 T\u2010cell count was 683 cells\/\u00b5L [interquartile range (IQR): 527\u2013910], and 95.4% had viral load \u2264\u00a050 copies\/mL. All performed the vaginal swab. Eighteen (27%) had no cervical smear results; none of these women attended HIV services where this was routinely offered. No cervical samples were positive for HR\u2010HPV. Three\u2010quarters (75.8%) of participants reported adherence to annual screening, with only one woman (1.5%) attending irregularly. On visual analogue scales (from 0 to 100), median (IQR) acceptability and necessity of smear tests were 100 (75\u2013100) and 100 (85\u2013100), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that the prevalence of HR\u2010HPV in WLWH in the UK may be low. Self\u2010sampling seems to be acceptable, suggesting, if validated, its potential role in supporting less frequent smear testing and improving screening uptake in WLWH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13257","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T02:28:28Z","timestamp":1646360908000},"page":"390-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Re\u2010valuation of annual cytology using HPV self\u2010sampling to upgrade prevention (REACH UP): A feasibility study in women living with HIV in the UK"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-966X","authenticated-orcid":false,"given":"Paola","family":"Cicconi","sequence":"first","affiliation":[{"name":"Nuffield Department of Medicine University of Oxford  Oxford UK"},{"name":"Department of Infectious Diseases Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanka","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Microbiology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Wareing","sequence":"additional","affiliation":[{"name":"Department of Microbiology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique Ingrid","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Microbiology Oxford University Hospitals NHS Foundation Trust  Oxford UK"},{"name":"Nuffield Division of Clinical Laboratory Science, Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Fox","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianne","family":"Lwanga","sequence":"additional","affiliation":[{"name":"Guy's and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisha","family":"Pal","sequence":"additional","affiliation":[{"name":"The Garden Clinic Upton Hospital  Slough UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Burns","sequence":"additional","affiliation":[{"name":"Institute for Global Health University College London  London UK"},{"name":"Royal Free London NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Woodward","sequence":"additional","affiliation":[{"name":"HIV and Genitourinary Medicine Milton Keynes University Hospital NHS Foundation Trust  Milton Keynes UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Malek","sequence":"additional","affiliation":[{"name":"Buckinghamshire Healthcare NHS Trust  Amersham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5173-2760","authenticated-orcid":false,"given":"Caroline Anne","family":"Sabin","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research Epidemiology, Modelling and Evaluation Institute for Global Health UCL  London UK"},{"name":"National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU) in Blood Borne and Sexually Transmitted Infections at UCL  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Dorrell","sequence":"additional","affiliation":[{"name":"Nuffield Department of Medicine University of Oxford  Oxford UK"},{"name":"Oxford NIHR Biomedical Research Centre  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(00)00125-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2018-000161"},{"key":"e_1_2_8_4_1","unstructured":"https:\/\/www.gov.uk\/guidance\/cervical\u2010screening\u2010programme\u2010overview. 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