{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:24:42Z","timestamp":1790504682253,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Women are underrepresented in most HIV clinical trials in Western countries, but their participation remains crucial as the lack of information on sex\u2010 and gender\u2010specific effects may hinder the safety and efficacy of antiretroviral treatments. The aim of this study was to identify barriers to and facilitators of women's participation in HIV clinical trials in Switzerland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted semi\u2010structured interviews among 20 women with HIV to explore factors associated with non\u2010participation in clinical trials. The interviewer presented to participants a clinical trial's description and discussed it with them. Lexicometric analysis on transcribed interviews identified three themes and eight sub\u2010themes related to the pros and cons of participation in HIV clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants evoked mainly decision\u2010making drivers, concerns for women living with HIV and treatment side\u2010effects. They highlighted the need for extensive information provided by trusted healthcare professionals on the research process as central to the decision to enrol in HIV clinical trials. Familial responsibilities were clearly identified as barriers to their participation, but not pregnancy. Additional preoccupations were other health concerns and comorbidities and the consequences of stopping ongoing antiretroviral treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To overcome the barriers to the participation of women living with HIV in clinical research in Western countries, healthcare professionals and researchers should increase women's research literacy by involving them in the study design and by tailoring clinical trials to their social roles and health concerns. Trust in professionals is a facilitator of enrolment of women living with HIV that should be maintained.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13259","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T09:39:50Z","timestamp":1645177190000},"page":"441-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Facilitators and barriers of women's participation in HIV clinical research in Switzerland: A qualitative study"],"prefix":"10.1111","volume":"23","author":[{"given":"Nelly","family":"Courvoisier","sequence":"first","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9) Department of Epidemiology and Health Systems University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Storari","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9) Department of Epidemiology and Health Systems University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saphir","family":"Lesage","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9) Department of Epidemiology and Health Systems University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Vittoz","sequence":"additional","affiliation":[{"name":"Center for Primary Care and Public Health (Unisant\u00e9) Department of Epidemiology and Health Systems University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Barbieux","sequence":"additional","affiliation":[{"name":"HIV\/AIDS Unit Department of Infectious Diseases Geneva University Hospitals  Geneva 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