{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:50:55Z","timestamp":1776747055728,"version":"3.51.2"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["2011\u2010375"],"award-info":[{"award-number":["2011\u2010375"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Population\u2010based universal test and treat (UTT) trials have shown an impact on population\u2010level virological suppression. We followed the ANRS 12249\u00a0TasP trial population for 6\u00a0years to determine whether the intervention had longer\u2010term survival benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The TasP trial was a cluster\u2010randomized trial in South Africa from 2012 to 2016. All households were offered 6\u2010monthly home\u2010based HIV testing. Immediate antiretroviral therapy (ART) was offered through trial clinics to all people living with HIV (PLHIV) in intervention clusters and according to national guidelines in control clusters. After the trial, individuals attending the trial clinics were transferred to the public ART programme. Deaths were ascertained through annual demographic surveillance. Random\u2010effects Poisson regression was used to estimate the effect of trial arm on mortality among (i) all PLHIV; (ii) PLHIV aware of their status and not on ART at trial entry; and (iii) PHLIV who started ART during the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mortality rates among PLHIV were 9.3\/1000 and 10.4\/1000 person\u2010years in the control and intervention arms, respectively. There was no evidence that the intervention decreased mortality among all PLHIV [adjusted rate ratio (aRR)\u00a0=\u00a01.10, 95% confidence interval (CI)\u00a0=\u00a00.85\u20131.43, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.46] or among PLHIV who were aware of their status but not on ART. Among individuals who initiated ART, the intervention decreased mortality during the trial (aRR\u00a0=\u00a00.49, 95% CI\u00a0=\u00a00.28\u20130.85, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01), but not after the trial ended.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The \u2018treat all\u2019 strategy reduced mortality among individuals who started ART but not among all PLHIV. To achieve maximum benefit of immediate ART, barriers to ART uptake and retention in care need to be addressed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13263","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T11:44:36Z","timestamp":1645875876000},"page":"922-928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early HIV treatment and survival over six years of observation in the ANRS 12249 Treatment as Prevention Trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-6625","authenticated-orcid":false,"given":"Kathy","family":"Baisley","sequence":"first","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"},{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Orne\u2010Gliemann","sequence":"additional","affiliation":[{"name":"University of Bordeaux Inserm Institut de Recherche pour le D\u00e9veloppement (IRD) UMR 1219  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-700X","authenticated-orcid":false,"given":"Joseph","family":"Larmarange","sequence":"additional","affiliation":[{"name":"Centre Population et D\u00e9veloppement (Ceped) Institut de Recherche pour le D\u00e9veloppement (IRD) Universit\u00e9 de Paris Inserm  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Plazy","sequence":"additional","affiliation":[{"name":"University of Bordeaux Inserm Institut de Recherche pour le D\u00e9veloppement (IRD) UMR 1219  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dami","family":"Collier","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity University College London  London UK"},{"name":"Cambridge Institute of Therapeutic Immunology &amp; Infectious Disease (CITIID)  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaco","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thobeka","family":"Mngomezulu","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kobus","family":"Herbst","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"},{"name":"DSI\u2010MRC South African Population Research Infrastructure Network  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"Hanekom","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"},{"name":"Division of Infection and Immunity University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Dabis","sequence":"additional","affiliation":[{"name":"University of Bordeaux Inserm Institut de Recherche pour le D\u00e9veloppement (IRD) UMR 1219  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3506-842X","authenticated-orcid":false,"given":"Mark J.","family":"Siedner","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"},{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-1717","authenticated-orcid":false,"given":"Collins","family":"Iwuji","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute  Durban South Africa"},{"name":"Department of Global Health and Infection Brighton and Sussex Medical School University of Sussex  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,26]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"UNAIDS.UNAIDS Data 2020.https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/2020_aids\u2010data\u2010book_en.pdf. 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