{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:21:10Z","timestamp":1792614070262,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical profile and outcome of patients with HIV\u2010associated plasmablastic lymphoma (PBL) treated with cyclophosphamide, doxorubicin, oncovin, prednisone (CHOP) chemotherapy in a tertiary hospital in KwaZulu\u2010Natal, South Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This 12\u2010year retrospective clinical chart review, from 2006 to 2018, of patients with PBL treated with CHOP chemotherapy describes their clinical presentation, complete response (CR), progression\u2010free survival (PFS) and disease\u2010free survival (DFS). Response to salvage chemotherapy was also assessed, as was the overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 26 patients included in the study, PBL was the presenting manifestation of underlying HIV infection in 58% (<jats:italic>n<\/jats:italic>\u00a0=\u00a015). The median age was 35\u00a0years (range 13\u201349), and 62% (<jats:italic>n<\/jats:italic>\u00a0=\u00a016) were males. The median CD4 count was 285 cells\/\u00b5L (range 45\u2013863). All patients had extranodal disease, with 4% having bone marrow involvement (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) and &gt;\u00a060% presenting with advanced stage and high\u2010risk PBL. Central nervous system (CNS) involvement was present in 15% (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). A CR was attained in 46% (<jats:italic>n<\/jats:italic>\u00a0=\u00a012). The median DFS was 23.5\u00a0months (range 5\u201391\u00a0months), with an overall 2\u2010year survival of 42% (<jats:italic>n<\/jats:italic>\u00a0=\u00a011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with PBL had a low CR with CHOP chemotherapy and poor OS. Use of alternative chemotherapy regimens needs to be investigated to optimally manage this aggressive lymphoma. The surprisingly low incidence of marrow involvement is the focus of ongoing local research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13266","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T10:33:15Z","timestamp":1646130795000},"page":"837-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["HIV\u2010associated plasmablastic lymphoma: A single\u2010centre 12\u2010year experience in Kwa\u2010Zulu Natal, South Africa"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-6078","authenticated-orcid":false,"given":"Nadine","family":"Rapiti","sequence":"first","affiliation":[{"name":"Department of Haematology NHLS\/University of KwaZulu Natal\/King Edward VIII Hospital  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasheeta","family":"Peer","sequence":"additional","affiliation":[{"name":"Non\u2010communicable Diseases Research Unit South African Medical Research Council  Durban South Africa"},{"name":"Department of Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Abdelatif","sequence":"additional","affiliation":[{"name":"Biostatistics Unit South African Medical Research Council  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Rapiti","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of KwaZulu Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunus","family":"Moosa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University of KwaZulu Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.1864.1864"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.06.023"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190400007789"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1413"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.124723"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-567479"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.15406\/htij.2018.06.00146"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800355"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1387912"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27551"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835e069d"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.911867"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.32.15_suppl.8583"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010015\u20100163\u2010z"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4561-9"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190290006260"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.12.039"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1113281"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000234"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_12_23_1","unstructured":"South Africa\u2019s National Strategic Plan on HIV TB and STIs 2017\u20102022(PDF) website. 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