{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:03:38Z","timestamp":1787313818793,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Healthcare workers in developing countries are at particularly increased risk of infections from blood\u2010borne pathogens because of the high prevalence of such pathogens in their communities as well as the lack of basic personal protective equipment, such as gloves, gowns and goggles. For those exposed healthcare workers, the immediate administration of antiretroviral drugs following exposure to potentially infected blood or other bodily fluids is essential in order to minimize the risk of acquiring HIV infection. This review is aimed at estimating the pooled prevalence of knowledge and uptake of post\u2010exposure prophylaxis among healthcare providers in Africa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We accessed PubMed, Science Direct, Google Scholar, SCOPUS, African Journals Online (AJOL), Journal Storage (JSTOR) and EMBASE. The search for unpublished studies included Google and institutional repositories were also used. This meta\u2010analysis follows the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) guidelines. The quality of studies was assessed using the modified Newcastle\u2010Ottawa Scale (NOS). Meta\u2010analysis was carried out with a random\u2010effects method using STATA v.14\u00a0software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 654\u00a0692 studies retrieved, 37\u00a0studies from four African regions involving 6482\u00a0healthcare providers were included in this meta\u2010analysis. The overall estimated pooled uptake and knowledge of HIV\/AIDS post\u2010exposure prophylaxis among healthcare providers in Africa using a random\u2010effects model were 40.09% (95% CI: 30.14\u201350.04) and 57.67% (95% CI: 44.32\u201371.01) respectively, whereas the highest uptake and knowledge were 45.48% (95% CI: 24.79\u201366.17) and 61.37% (95% CI: 46.39\u201376.36) in the southern and eastern regions, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this meta\u2010analysis indicated that the knowledge and uptake of post\u2010exposure prophylaxis, one of the best approaches to tackling HIV\/AIDS transmission, are significantly low. Therefore, healthcare organizations should work on strategies to increase knowledge and uptake of post\u2010exposure prophylaxis among healthcare providers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>Prospero (ID: CRD42021244003).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.13271","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T02:24:41Z","timestamp":1648693481000},"page":"811-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["HIV\/AIDS post\u2010exposure prophylaxis knowledge and uptake among health professionals in Africa: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4200-4216","authenticated-orcid":false,"given":"Tiwabwork","family":"Tekalign","sequence":"first","affiliation":[{"name":"School of Nursing College of Health Science and Medicine Wolaita Sodo University  Sodo Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1037-5004","authenticated-orcid":false,"given":"Nefsu","family":"Awoke","sequence":"additional","affiliation":[{"name":"School of Nursing College of Health Science and Medicine Wolaita Sodo University  Sodo Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirubel","family":"Eshetu","sequence":"additional","affiliation":[{"name":"School of Nursing College of Health Science and Medicine Wolaita Sodo University  Sodo Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belete","family":"Gelaw Walle","sequence":"additional","affiliation":[{"name":"School of Nursing College of Health Science and Medicine Wolaita Sodo University  Sodo Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mistire","family":"Teshome Guta","sequence":"additional","affiliation":[{"name":"School of Nursing College of Health Science and Medicine Wolaita Sodo University  Sodo Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000218543.46963.6d"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39211.403970.BE"},{"key":"e_1_2_9_4_1","unstructured":"Joint United Nations Programme on HIV\/AIDS.Global HIV&AIDS statistics fact sheet.2018. 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