{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:21:50Z","timestamp":1790720510197,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the incidence of hypertension in people living with HIV receiving integrase strand transfer inhibitor (INSTI)\u2010based antiretroviral therapy (ART) versus non\u2010nucleoside reverse transcriptase inhibitors (NNRTIs) or boosted protease inhibitors (PIs) in the RESPOND consortium of HIV cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible people with HIV were aged \u226518\u00a0years who initiated a new three\u2010drug ART regimen for the first time (baseline), did not have hypertension, and had at least two follow\u2010up blood pressure (BP) measurements. Hypertension was defined as two consecutive systolic BP measurements \u2265140\u00a0mmHg and\/or diastolic BP \u226590\u00a0mmHg or initiation of antihypertensives. Multivariable Poisson regression was used to determine adjusted incidence rate ratios (aIRRs) of hypertension, overall and in those who were ART na\u00efve or experienced at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 4606 people living with HIV were eligible (INSTIs\u00a03164, NNRTIs\u00a0807, PIs\u00a0635). The median baseline systolic BP, diastolic BP, and age were 120 (interquartile range [IQR] 113\u2013130) mmHg, 78 (70\u201382) mmHg, and 43 (34\u201350) years, respectively. Over 8380.4 person\u2010years (median follow\u2010up 1.5 [IQR 1.0\u20132.7]\u00a0years), 1058 (23.0%) participants developed hypertension (incidence rate 126.2\/1000 person\u2010years, 95% confidence interval [CI] 118.9\u2013134.1). Participants receiving INSTIs had a higher incidence of hypertension than those receiving NNRTIs (aIRR 1.76; 95% CI 1.47\u20132.11), whereas the incidence was no different in those receiving PIs (aIRR 1.07; 95% CI 0.89\u20131.29). The results were similar when the analysis was stratified by ART status at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although unmeasured confounding and channelling bias cannot be excluded, INSTIs were associated with a higher incidence of hypertension than were NNRTIs, but rates were similar to those of PIs overall, in ART\u2010na\u00efve and ART\u2010experienced participants within RESPOND.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13273","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T02:34:49Z","timestamp":1646188489000},"page":"895-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Incidence of hypertension in people with HIV who are treated with integrase inhibitors versus other antiretroviral regimens in the RESPOND cohort 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