{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:44:21Z","timestamp":1774597461321,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>International lockdowns during the COVID\u201019 pandemic impacted antiretroviral drug supplies in Indonesia. We assessed the impact of antiretroviral treatment (ART) provision and being lost to follow\u2010up (LTFU) on people living with HIV, attending a key population\u2010focused HIV clinic in Denpasar, Bali.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective note review of anonymized data from adult Indonesian patients living with HIV. We collected demographic data and information on being LTFU, and assessed the numbers of patients impacted by ART switches from fixed\u2010dose combination (FDC) tenofovir\/lamivudine\/efavirenz to multi\u2010pill zidovudine\u2010based regimens, during the first international lockdown from March 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Records of 260 Indonesian adult patients registered for HIV care and prescribed ART were reviewed; 240 (92.3%) were men, and 90% were men who have sex with men. Between 13 March and 28 May 2020, 214 (87%) out of 247 patients (previously diagnosed with HIV) had to switch to individual, multi\u2010pill zidovudine\u2010based regimens from their FDC. The switch lasted a mean of 35\u00a0days (range 10\u201385). Twenty\u2010five patients (10%) were LTFU; patients who switched were more likely to remain in care. Data on viral load status and toxicity are lacking as laboratory testing requires self\u2010payment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of patients living with HIV had no choice but to switch to multi\u2010pill, zidovudine\u2010based regimens.<\/jats:p><jats:p>Despite significant efforts to minimize the impact of lockdown on care, 10% of patients were LTFU. Patients switching ART required greater clinic attention and support, improving retention.<\/jats:p><jats:p>Complete national data are needed to understand the impact of ART stockouts on virological suppression and drug resistance throughout Indonesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13298","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T09:54:03Z","timestamp":1647856443000},"page":"1025-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antiretroviral drug switches to zidovudine\u2010based regimens and loss to follow\u2010up during the first COVID\u201019 lockdown in Bali, Indonesia"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5797-8216","authenticated-orcid":false,"given":"Keerti","family":"Gedela","sequence":"first","affiliation":[{"name":"Chelsea &amp; Westminster NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngurah","family":"Rajus","sequence":"additional","affiliation":[{"name":"Yayasan Bali Peduli HIV\/Sexual Health Clinic  Denpasar Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendry","family":"Luis","sequence":"additional","affiliation":[{"name":"Yayasan Bali Peduli HIV\/Sexual Health Clinic  Denpasar Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5082-8656","authenticated-orcid":false,"given":"Wayan Dede","family":"Fridayantara","sequence":"additional","affiliation":[{"name":"Yayasan Bali Peduli HIV\/Sexual Health Clinic  Denpasar Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwanto","family":"Irwanto","sequence":"additional","affiliation":[{"name":"Pusat Unggulan Kebijakan Kesehatan dan Inovasi Sosial (PUI\u2010PT PPH, PUK21S) HIV\/AIDS Research Centre Atma Jaya Catholic University  Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evi","family":"Sukmaningrum","sequence":"additional","affiliation":[{"name":"Pusat Unggulan Kebijakan Kesehatan dan Inovasi Sosial (PUI\u2010PT PPH, PUK21S) HIV\/AIDS Research Centre Atma Jaya Catholic University  Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank Stephen","family":"Wignall","sequence":"additional","affiliation":[{"name":"Yayasan Bali Peduli HIV\/Sexual Health Clinic  Denpasar Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"UNAIDS data 2019.https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/2019\u2010UNAIDS\u2010data_en.pdf. Accessed February 15 2022."},{"key":"e_1_2_8_3_1","unstructured":"HIV epidemiology review Indonesia 2016.Indonesia: Kementerian Kesehatan Republic Indonesia\/World Health Organization: Directorate General of Disease Prevention and Control Ministry of Health Republic of Indonesia 2017."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30138-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010539520962611"},{"issue":"9","key":"e_1_2_8_6_1","first-page":"E1132","article-title":"The potential impact of the COVID\u201019 epidemic on HIV, TB and malaria in low\u2010 and middle\u2010income countries: a modelling study","volume":"8","author":"Hogan AB","year":"2020","journal-title":"Lancet"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32526\u20105"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30148-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-009-9590-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-021-01583-z"},{"key":"e_1_2_8_11_1","unstructured":"TREAT Asia Special Report: Expanded Availability of HIV\/AIDS Drugs in Asia Creates Urgent Need for Trained Doctors July 2004.https:\/\/www.hivpolicy.org\/Library\/HPP000544.pdf. Accessed February 15 2022."},{"key":"e_1_2_8_12_1","unstructured":"Increasing access to HIV treatment in middle\u2010income countries Key data on prices regulatory status tariffs and the intellectual property situation. World Health Organisation 2014.https:\/\/www.who.int\/phi\/publications\/WHO_Increasing_access_to_HIV_treatment.pdf. Accessed February 15 2022."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462420966838"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00536-8"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.13298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:51:41Z","timestamp":1692751901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,21]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/hiv.13298"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13298","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,21]]},"assertion":[{"value":"2022-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}