{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:13:27Z","timestamp":1747185207693,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Renal disease prevalence varies widely amongst reported cohorts of people living with HIV (PLWHIV) in sub\u2010Saharan Africa. Renal function testing is not routine in those commencing antiretroviral therapy (ART) in the region, however. Further data on renal disease prevalence and the change associated with ART use are therefore needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore changes in renal function and associated predictors after 1\u00a0year of ART in an adult cohort of PLWHIV from Zimbabwe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of patients who attended the Newlands Clinic between January 2007 and September 2019. Eligible patients were aged \u226518\u00a0years and had measures of serum creatinine at baseline and after 1\u00a0year of ART. Predictors of renal function change were assessed by multiple linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>1729 patients were eligible for inclusion. Median age was 36\u00a0years (IQR 30\u201343) and 62.8% were female. After 1\u00a0year of ART, the proportion of patients with an estimated glomerular filtration rate (eGFR) &lt;60\u00a0ml\/min\/1.73<jats:sup>2<\/jats:sup> did not significantly change (2.0% vs. 1.2%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.094), but there was a decrease in the proportion of patients with proteinuria (11.0% vs. 5.6%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Hypertension (B\u00a0=\u00a0\u22126.43; 95% CI \u22128.97 to \u22123.89; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and baseline proteinuria (B\u00a0=\u00a0\u22127.33; 95% CI \u221210.25 to \u22124.42; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) were negative predictors of change in eGFR from baseline, whereas diabetes status was not associated (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.476).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Proteinuria was common, but its prevalence halved after 1\u00a0year of ART. Screening for hypertension could be a simple way to identify patients at risk of renal function decline.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13303","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T09:56:14Z","timestamp":1649411774000},"page":"1002-1006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of renal impairment and proteinuria after commencement of antiretroviral therapy in a Zimbabwean HIV cohort"],"prefix":"10.1111","volume":"23","author":[{"given":"Douglas","family":"Drak","sequence":"first","affiliation":[{"name":"Royal North Shore Hospital  St Leonards NSW Australia"},{"name":"Central Clinical School Faculty of Medicine The University of Sydney  Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-4754","authenticated-orcid":false,"given":"Jack E.","family":"Heron","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Royal Prince Alfred Hospital  Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tinei","family":"Shamu","sequence":"additional","affiliation":[{"name":"Newlands Clinic  Harare Zimbabwe"},{"name":"Institute of Social and Preventive Medicine University of Bern  Bern Switzerland"},{"name":"Graduate School of Health Sciences University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleophas","family":"Chimbetete","sequence":"additional","affiliation":[{"name":"Newlands Clinic  Harare Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumbi","family":"Dahwa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences University of Zimbabwe  Harare Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Gracey","sequence":"additional","affiliation":[{"name":"Central Clinical School Faculty of Medicine The University of Sydney  Sydney NSW Australia"},{"name":"Department of Renal Medicine Royal Prince Alfred Hospital  Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.14863.3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195443"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.141"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.03.008"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu117"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30432-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm223"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328307a051"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/533468"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040388"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332378"},{"key":"e_1_2_9_14_1","unstructured":"PetersP MooreD MerminJ BrooksJ DowningR WereW editors.Renal function improves among Ugandans on NNRTI\u2010based HAART: 24\u2010month follow\u2010up from the home\u2010based AIDS care program in rural Uganda. Proceedings of the 14th Conference on Retrovirsuses and Opportunistic Infections; 2007."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/135965350701200812"},{"issue":"1","key":"e_1_2_9_16_1","first-page":"1","article-title":"Renal dysfunction among anti\u2010retroviral therapy na\u00efve HIV infected patients in Zimbabwe","volume":"57","author":"Fana G","year":"2011","journal-title":"Cent Afr J Med"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy216"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-11-35"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12663"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138991"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089573"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hiv.13303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:50:39Z","timestamp":1692751839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,8]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/hiv.13303"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13303","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"type":"print","value":"1464-2662"},{"type":"electronic","value":"1468-1293"}],"subject":[],"published":{"date-parts":[[2022,4,8]]},"assertion":[{"value":"2021-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}