{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:25:20Z","timestamp":1769153120749,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our objective was to determine whether antiretroviral drugs (ARVs) were used according to the European AIDS Clinical Society (EACS) guidelines for people with HIV\/hepatitis C virus (HCV) coinfection treated with direct\u2010acting antivirals (DAAs) between 30 November 2014 and 31 December 2019 in the pan\u2010European EuroSIDA study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At each publication date of the EACS guidelines, plus 3 and 6\u2009months, we calculated the number of people receiving DAAs with potential and actual ARV contraindications (\u2018red shading\u2019 in the EACS guidelines). We used logistic regression to investigate factors associated with using contraindicated ARVs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1406 people starting DAAs, the median age was 51\u2009years, 75% were male, 57% reported injected drug use as an HIV risk, and 76% were from western Europe. Of 1624 treatment episodes, 609 (37.5%) occurred while the patient was receiving ARVs with potential contraindications; among them, 38 (6.2%; 95% confidence interval [CI] 4.3\u20138.2) involved a contraindicated ARV (18 non\u2010nucleoside reverse transcriptase inhibitors), 16 involved protease inhibitors, and four involved integrase strand transfer inhibitors. The adjusted odds of receiving a contraindicated ARV were higher (3.25; 95% CI 1.40\u20137.57) among participants from east\/central east Europe (vs. south) and lower (0.22; 95% CI 0.08\u20130.65) for 2015\u20132018 guidelines (vs. 2014). In total, 29 of the 32 (90.6%) patients receiving a contraindicated ARV and 441 of the 461 (95.7%) with potential ARV contraindications experienced a sustained virological response \u226512\u2009weeks after stopping treatment (SVR12; <jats:italic>p<\/jats:italic>\u00a0=\u20090.55).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large heterogenous European cohort, more than one\u2010third of people with HIV\/HCV coinfection received DAAs with potential ARV contraindications, but few received a contraindicated ARV. Use of contraindicated ARVs declined over time, corresponding to the increased availability of ARV therapy regimens without interactions with DAA across Europe. Participants who received a contraindicated DAA and ARV combination still had a high rate of SVR12.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13357","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T07:05:39Z","timestamp":1659942339000},"page":"224-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of contraindicated antiretroviral drugs in people with <scp>HIV<\/scp>\/<scp>HCV<\/scp> coinfections receiving <scp>HCV<\/scp> treatment with direct\u2010acting antivirals\u2014Results from the <scp>EuroSIDA<\/scp> study"],"prefix":"10.1111","volume":"24","author":[{"given":"Myroslava","family":"Nikolaichuk","sequence":"first","affiliation":[{"name":"Department of the Infectious Diseases Dnipro State Medical University  Dnipro Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Mocroft","sequence":"additional","affiliation":[{"name":"CHIP, Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Centre for Clinical Research, Epidemiology Modelling and Evaluation (CREME), Institute for Global Health, UCL  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Wandeler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Szlavik","sequence":"additional","affiliation":[{"name":"South\u2010Pest Hospital Centre\u2014National Institute for Infectology and Haematology  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Gottfredsson","sequence":"additional","affiliation":[{"name":"Landspitali University Hospital  Reykjavik Iceland"},{"name":"Faculty of Medicine School of Health Sciences, University of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dag Henrik","family":"Reikvam","sequence":"additional","affiliation":[{"name":"Department of Infectious diseases Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Svedhem","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hila","family":"Elinav","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases Hadassah Hospital  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Laguno","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Hospital Clinic  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Mansinho","sequence":"additional","affiliation":[{"name":"Hospital de Egas Moniz  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Devitt","sequence":"additional","affiliation":[{"name":"Department of Genitourinary Medicine and Infectious Diseases St James's Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-825X","authenticated-orcid":false,"given":"Nikoloz","family":"Chkhartishvili","sequence":"additional","affiliation":[{"name":"Infectious Diseases AIDS &amp; Clinical Immunology Research Center  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3111-621X","authenticated-orcid":false,"given":"Georg","family":"Behrens","sequence":"additional","affiliation":[{"name":"Medizinische Hochschule Hannover  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Bogner","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Medizinische Klinik und Poliklinik IV, Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"Viard","sequence":"additional","affiliation":[{"name":"Diagnostic and Therapeutic Center H\u00f4tel\u2010Dieu, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5847-8416","authenticated-orcid":false,"given":"Alan","family":"Winston","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Benfield","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford","family":"Leen","sequence":"additional","affiliation":[{"name":"Western General Hospital  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Fursa","sequence":"additional","affiliation":[{"name":"CHIP, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Rockstroh","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Peters","sequence":"additional","affiliation":[{"name":"CHIP, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the EuroSIDA study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.026"},{"key":"e_1_2_8_3_1","unstructured":"European AIDS Clinical Society.EACS Guidelines. 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