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Duncan Cancer Center, Baylor College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019346","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA206476"],"award-info":[{"award-number":["R01CA206476"]}],"id":[{"id":"10.13039\/100019346","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>People living with HIV have high rates of obesity and obesity\u2010related comorbidities. Our study sought to evaluate weight trajectory in a retrospective cohort of people living with HIV and matched HIV\u2010negative veterans (controls) and to evaluate risk factors for weight gain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective database analysis of data extracted from the VA Corporate Data Warehouse that included people living with HIV (n\u00a0=\u00a022\u2009421) and age\u2010matched HIV\u2010negative controls (n\u00a0=\u00a063\u2009072). The main outcomes were baseline body weight and weight change from baseline at 1, 2, and 5\u2009years after diagnosis (baseline visit for controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Body weight at baseline was lower in people living with HIV than in controls. People living with HIV on antiretroviral therapy (ART) gained more weight than did controls. In a sub\u2010analysis of ART\u2010exposed people living with HIV, age\u2009&gt;50\u2009years, African American race, body mass index (BMI)\u2009&lt;25, CD4\u2009\u2264200, and HIV diagnosis year after 2000 were associated with more weight gain at year 1. Nucleoside reverse transcriptase inhibitors (NRTI)\u00a0plus\u2009non\u2010NRTIs (NNRTIs) were associated with less weight gain than NRTIs\u2009plus\u2009protease inhibitors, NRTIs\u2009plus\u2009integrase inhibitors, or NRTIs\u2009plus\u2009other agents at year 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among US veterans, those living with HIV had lower rates of obesity than age\u2010matched HIV\u2010negative controls; however, primarily in the first 2\u2009years after starting ART, people living with HIV gained more weight than did controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13366","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T07:29:27Z","timestamp":1659684567000},"page":"180-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of <scp>HIV<\/scp> and antiretroviral therapy use on body weight changes in a cohort of U.S. veterans living with and without <scp>HIV<\/scp>"],"prefix":"10.1111","volume":"24","author":[{"given":"Jose M.","family":"Garcia","sequence":"first","affiliation":[{"name":"Geriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Health Care System, and Department of Medicine, Division of Gerontology &amp; Geriatric Medicine University of Washington School of Medicine  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongquan","family":"Dong","sequence":"additional","affiliation":[{"name":"VA Health Services Research Center of Innovations in Quality Effectiveness and Safety (IQuESt), Michael E. 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