{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:33:39Z","timestamp":1775684019815,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assessed real\u2010world weight change and pregnancy outcomes among pregnant women living with HIV who used integrase strand transferase inhibitor (INSTI)\u2010based combined antiretroviral therapy (cART).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective cohort study from 2014 to 2021 for prevention of perinatal HIV infection, we evaluated changes in weight from the first prenatal visit to near delivery for two groups. The categories of change were: low (&lt;\u20090.18\u2009kg\/week), normal (0.18\u20130.59\u2009kg\/week), and high (&gt;\u20090.59\u2009kg\/week). The backbones were lamivudine + tenofovir disoproxil or lamivudine + zidovudine. The comparison groups were women with body mass index (BMI)\u2009&lt;\u200925\u2009kg\/m<jats:sup>2<\/jats:sup> versus BMI \u2265\u200925\u2009kg\/m<jats:sup>2<\/jats:sup> and INSTI\u2010na\u00efve versus INSTI\u2010experienced. Continuous variables were analysed with a Kruskal\u2013Wallis test and count or categorical data with \u03c7<jats:sup>2<\/jats:sup> tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 198 pregnant women. At study entry, 74 had BMI\u2009&lt;\u200925\u2009kg\/m<jats:sup>2<\/jats:sup> and 124 had BMI \u2265\u200925\u2009kg\/m<jats:sup>2<\/jats:sup>. Excess gestational weight gain was more frequent among women who were INSTI\u2010na\u00efve among both BMI groups (&lt;\u200925 and \u2265\u200925). However, the proportion of participants per weight change category was only significantly different between INSTI\u2010na\u00efve women with baseline BMI\u2009&lt;\u200925\u2009kg\/m<jats:sup>2<\/jats:sup> and INSTI\u2010experienced women with BMI\u2009&lt;\u200925 kg\/m<jats:sup>2<\/jats:sup>. In particular, INSTI\u2010na\u00efve women with BMI\u2009&lt;\u200925\u2009kg\/m<jats:sup>2<\/jats:sup> had significantly higher rates of excess gestational weight gain (31.6%) compared with participants with BMI\u2009&lt;\u200925\u2009kg\/m<jats:sup>2<\/jats:sup> who conceived while on INSTIs (11.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004). Rates of unfavourable pregnancy outcomes were low and did not differ significantly between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>INSTI\u2010na\u00efve participants with BMI\u2009&lt;\u200925 kg\/m<jats:sup>2<\/jats:sup> gained more weight during pregnancy than participants with BMI \u2265\u200925 kg\/m<jats:sup>2<\/jats:sup> who conceived while using INSTIs. Rates of adverse pregnancy outcomes did not differ between the groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13388","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T05:44:50Z","timestamp":1662443090000},"page":"301-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Real\u2010world experience with weight gain among pregnant women living with <scp>HIV<\/scp> who are using integrase inhibitors"],"prefix":"10.1111","volume":"24","author":[{"given":"Trevon","family":"Fuller","sequence":"first","affiliation":[{"name":"Infectious Diseases Department Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"},{"name":"University of California Los Angeles, Institute of the Environment and Sustainability  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Fragoso da Silveira Gouv\u00eaa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"},{"name":"Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Lourdes","family":"Benamor Teixeira","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"},{"name":"Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Ferreira Medeiros","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Amorim da Silva","sequence":"additional","affiliation":[{"name":"Maternal Fetal Unit Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camile","family":"Medeiros Braga","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Constan Werneck Sant'anna","sequence":"additional","affiliation":[{"name":"Maternal Fetal Unit Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariza","family":"de Mattos Salgueiro","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarisse","family":"da Silveira Bressan","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"},{"name":"Instituto Nacional de Infectologia Evandro Chagas, Funda\u00e7\u00e3o Oswaldo Cruz  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wallace","family":"Mendes\u2010Silva","sequence":"additional","affiliation":[{"name":"Maternal Fetal Unit Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0627","authenticated-orcid":false,"given":"Esau C.","family":"Jo\u00e3o","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital Federal dos Servidores do Estado  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Updated Recommendations on HIV Prevention, Infant Diagnosis, Antiretroviral Initiation and Monitoring","author":"World Health Organization","year":"2021"},{"key":"e_1_2_10_3_1","volume-title":"Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV","author":"U.S. Department of Health and Human Services Panel on Antiretroviral Guidelines for Adults and Adolescents Panel Members and Consultants","year":"2021"},{"key":"e_1_2_10_4_1","volume-title":"Guidelines. 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Denver 2022:273\u20134."},{"key":"e_1_2_10_11_1","unstructured":"HoffmanRM ZiembaL BrummelS et al.Antenatal weight gain and adverse pregnancy outcomes in IMPAACT 2010. Oral Abstracts No. 176. Conference on Retroviruses and Opportunistic Infections Abstract eBook. 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