{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:19:18Z","timestamp":1759331958915,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015652","name":"Barts Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The great success of HIV treatments means that, increasingly, people living with HIV (PLHIV) are growing old enough to develop age\u2010associated comorbid conditions. We investigated the evolution of comorbid conditions and demographics among PLHIV in England.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study linking Clinical Practice Research Datalink (CPRD) primary care, hospitalization, death registry and Index of Multiple Deprivation data, we measured the prevalence of 304 individual health conditions, categorized into 47 condition groups (36 non\u2010communicable, 11 communicable). Using logistic regression, we calculated odds ratios (ORs) for the likelihood of each condition and condition group in 2015 versus 2008, adjusting for age, sex and deprivation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2015, there were 964 CPRD\u2010registered PLHIV compared with 1987 in 2008; 62% were male and 38% female in both cohorts. The 2015 cohort was older, with 51.1% aged 45\u201364\u2009years and 7.2% aged 65\u201384\u2009years compared with 31.8% and 3.2%, respectively, in 2008. Deprivation was higher in 2015, at 23.9% (quintile 4) and 28.7% (quintile 5) compared with 5.8% and 6.6%, respectively, in 2008.<\/jats:p><jats:p>Of 36 non\u2010communicable condition groups, 14 (39%) occurred in \u2265\u200910% of PLHIV in 2015, of which seven were more likely in 2015 than in 2008: renal\u2010chronic\u2010kidney\u2010disease [odds ratio (OR)\u00a0=\u20091.96 (95% CI: 1.33\u20132.90); endocrine\u2010obesity [OR\u00a0=\u00a01.76 (1.12\u20132.77)]; rheumatology [OR\u00a0=\u00a01.64 (1.30\u20132.07)]; dermatology [OR\u00a0=\u00a01.55(1.29\u20131.85)]; genito\u2010urinary\u2010gynaecological [OR\u00a0=\u00a01.44(1.18\u20131.76)]; eyes\u2010ears\/nose\/throat [OR\u00a0=\u00a01.31(1.08\u20131.59)]; and gastro\u2010intestinal conditions [OR\u00a0=\u00a01.28 (1.04\u20131.58)]. Two condition groups, respiratory\u2010chronic\u2010obstructive\u2010pulmonary\u2010disease [OR\u00a0=\u00a00.36 (0.19\u20130.69)] and endocrine\u2010diabetes [OR\u00a0=\u00a00.49 (0.34\u20130.70)], were less likely in 2015. Ten out of 11 communicable infectious condition groups were less likely in 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although infections in PLHIV have fallen, chronic non\u2010communicable comorbidity is increasingly prevalent. Alongside the marked increases in deprivation and ageing, this study suggests that socio\u2010economic measures in addition to healthcare provision are needed to achieve holistic health for PLHIV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13389","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T05:29:16Z","timestamp":1663651756000},"page":"311-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Changing co\u2010morbidity and increasing deprivation among people living with HIV: UK population\u2010based cross\u2010sectional study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9757-9754","authenticated-orcid":false,"given":"Patricia","family":"McGettigan","sequence":"first","affiliation":[{"name":"William Harvey Research Institute Queen Mary University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-8069","authenticated-orcid":false,"given":"Daniel R.","family":"Morales","sequence":"additional","affiliation":[{"name":"Division of Population Health and Genomics University of Dundee  Dundee UK"},{"name":"Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-6235","authenticated-orcid":false,"given":"David","family":"Moreno\u2010Martos","sequence":"additional","affiliation":[{"name":"Division of Population Health and Genomics University of Dundee  Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nashaba","family":"Matin","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust, Grahame Hayton Unit Royal London Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"MartinV ShahA MackayN LesterJ Newbigging\u2010ListerA ConnorN BrownAE SullivanAK DelpechVC and contributors.HIV testing new HIV diagnoses outcomes and quality of care for people accessing HIV services: 2021 report. 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