{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:27:48Z","timestamp":1792042068461,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:00:00Z","timestamp":1681603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Women with HIV are more often infected with human papillomavirus (HPV) and are more prone to develop precancerous cervical lesions (squamous intraepithelial lesions, SIL) and invasive cervical cancer (ICC) than HIV\u2010negative women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This scoping\u2010review analyses the impact of HIV on HPV prevalence, incidence and evolution to SIL and ICC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected all PubMed systematic reviews and meta\u2010analyses published between January 2000 and July 2021 reporting data about HPV, cervical intraepithelial neoplasia (CIN), SIL and ICC prevalence, incidence and evolution in women with HIV. A hypothetical model comparing the history of HPV infection in HIV\u2010negative, combined antiretroviral therapy (cART)\u2010treated and \u2010untreated women with HIV was built.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 11 meta\u2010analyses and 10 systematic reviews were selected, which included between 770 and 236\u2009127 women with HIV. Women with HIV have a 3 to 6 times higher risk of being infected by HPV, of progression to high\u2010grade SIL (HSIL) and to ICC. These risks are exacerbated when the CD4 cell counts are low and when they are not using cART, whereas these risks are reduced by 20%\u201330% when they are optimally treated with cART and have had a suppressed HIV viral load for at least 2\u2009years. In our model, we illustrated that optimal HIV treatment and preventing HIV reduce the number of ICC cases by 2.5 and 6 times, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Optimal treatment and care of HIV patients are essential to reduce their prevalence of ICC, as are preventive strategies which include HPV vaccination, cervical cancer screening strategies and treatment of HSIL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13490","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T04:05:10Z","timestamp":1681704310000},"page":"877-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The recent natural history of human papillomavirus cervical infection in women living with <scp>HIV<\/scp>: A scoping review of meta\u2010analyses and systematic reviews and the construction of a hypothetical 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