{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:11:07Z","timestamp":1774444267688,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dolutegravir (DTG) plus lamivudine (3TC) has proven highly efficacious as a switching strategy in virologically suppressed people with HIV (PWH). As this strategy was introduced relatively recently, real\u2010world, long\u2010term durability studies are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective review of treatment\u2010experienced patients who started DTG\u2009+\u20093TC in a cohort of PWH. HIV\u2010RNA &lt;50 copies\/mL was analysed at 144\u2009weeks in an intention\u2010to\u2010treat (ITT) analysis (missing\u2009=\u2009failure) and a per\u2010protocol (PP) analysis (patients with missing data or changes for reasons other than virological failure were excluded).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population comprised 358 PWH (19% women). Median age and time with HIV infection were 51.7 and 13.4\u2009years, respectively. The median number of previous antiretroviral combinations was three. Previous virological failure was reported in 27.1% of patients, and the M184V resistance mutation was detected in 17 patients. At 144\u2009weeks, the percentage of individuals with HIV\u2010RNA &lt;50 copies\/mL was 77.4% (277\/358) in the ITT analysis and 95.5% (277\/290) in the PP analysis. A total of 68 participants were excluded from the PP analysis (data missing, 25, discontinuation due to toxicity, 19; other, 16; death, 8). Two people with virological failure selected resistance\u2010associated mutations (M184V and M184V\u2009+\u2009R263K). HIV\u2010RNA remained undetectable in 17 patients with a previous history of the M184V mutation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results confirm the real\u2010world, long\u2010term efficacy, tolerability and high genetic barrier of DTG\u2009+\u20093TC in treatment\u2010experienced PWH. Although scarce, mutations causing resistance to nucleosides and integrase can emerge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13500","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T05:46:12Z","timestamp":1684302372000},"page":"1013-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Three\u2010year efficacy of switching to dolutegravir plus lamivudine: A real\u2010world study"],"prefix":"10.1111","volume":"24","author":[{"given":"E.","family":"Palmier","sequence":"first","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"De Miguel","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Montejano","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Busca","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mic\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cadi\u00f1anos","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Serrano","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. I.","family":"Bernardino","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-7135","authenticated-orcid":false,"given":"I.","family":"P\u00e9rez\u2010Valero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Valencia","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Arribas","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Montes","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gonz\u00e1lez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"},{"name":"CIBER Infectious Diseases (CIBERINFEC)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mart\u00edn\u2010Carbonero","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2021.1887135"},{"issue":"83","key":"e_1_2_7_3_1","first-page":"310","article-title":"Durable efficacy of dolutegravir plus lamivudine in antiretroviral treatment\u2013naive adults with HIV\u20101 infection: 96\u2010week results from the GEMINI\u20101 and GEMINI\u20102 randomized clinical trials","volume":"2020","author":"Cahn P","year":"1999","journal-title":"J Acquir Immune Defic Syndromes"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1243"},{"key":"e_1_2_7_5_1","article-title":"Efficacy and safety of switching to the 2\u2010drug regimen dolutegravir\/lamivudine versus continuing a 3\u2010 or 4\u2010drug regimen for maintaining virologic suppression in adults living with HIV\u20101: week 48 results from the phase 3, non\u2010inferiority SALSA randomized trial","author":"Llibre JM","year":"2022","journal-title":"Clin Infect Dis"},{"key":"e_1_2_7_6_1","unstructured":"EACS GUIDELINES."},{"key":"e_1_2_7_7_1","volume-title":"Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV","author":"Panel on Antiretroviral Guidelines for Adults and Adolescents"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016813"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13050"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-021-00522-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105893"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac036"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07769-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2022.07.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002787"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac610"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13146"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz256"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1083"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003070"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac082"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab323"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T02:56:03Z","timestamp":1707706563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/hiv.13500"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13500","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"assertion":[{"value":"2023-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}