{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:13:51Z","timestamp":1747185231249,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Lower urinary tract symptoms (LUTS) are becoming more prevalent in the ageing population of males living with HIV. Drugs to treat LUTS are known for both their potential role as victims in drug\u2013drug interactions (DDIs) and their side effects. We aimed to evaluate the current use of drugs to treat LUTS and to assess potential DDIs in our cohort of adult males living with HIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a retrospective review of pharmacy records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recorded the combination antiretroviral therapy (cART) regimen and any use of drugs to treat LUTS (anatomical therapeutic chemical codes G04CA\/CB\/CX and G04BD). Potential DDIs were assessed using the interaction checker developed by the University of Liverpool (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.hiv-druginteractions.org\/checker\">https:\/\/www.hiv-druginteractions.org\/checker<\/jats:ext-link>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 411 adult males living with HIV were included in this analysis. The median (interquartile range [IQR]) age was 53 (41\u201362) years. Nineteen (4.6%) patients used one or more drugs to treat LUTS. As expected, older patients were more likely to be receiving treatment for LUTS: Q1 (20\u201340\u2009years) =\u20090%; Q2 (41\u201352\u2009years) =\u20092%; Q3 (53\u201361\u2009years) =\u20097%; Q4 (62\u201379\u2009years) =\u200910%. Seven potential DDIs between cART and LUTS treatment were noted in six of the 19 (32%) patients. Following medication reviews of these six patients, the following interventions were proposed: evaluate safe use of alpha\u2010blocker (<jats:italic>n<\/jats:italic>\u2009=\u20094), change in cART (<jats:italic>n<\/jats:italic>\u2009=\u20092), and dose reduction of the anticholinergic agent (<jats:italic>n<\/jats:italic>\u2009=\u20091).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment for LUTS coincided with cART in 7%\u201310% of patients aged above the median age of 53\u2009years in our cohort. Improvements in DDI management appeared to be possible in this growing cohort of males living with HIV and with LUTS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13519","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T06:30:56Z","timestamp":1686292256000},"page":"1083-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential drug\u2013drug interactions in males living with <scp>HIV<\/scp> who use drugs to treat lower urinary tract symptoms"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7279-2818","authenticated-orcid":false,"given":"David","family":"Burger","sequence":"first","affiliation":[{"name":"Department of Pharmacy Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Global DDI Solutions  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piter","family":"Oosterhof","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Pharmacy OLVG Hospital  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Grintjes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Marneef\u2010Pietersma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-289X","authenticated-orcid":false,"given":"Frank","family":"d'Ancona","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoye","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Keijmel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Richel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinout","family":"van Crevel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-4340","authenticated-orcid":false,"given":"David","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2019.1627200"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa505"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-018-0789-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12695"},{"key":"e_1_2_8_6_1","unstructured":"EACS.The European Guidelines for the treatment of HIV\u2010positive adults in Europe: version 11.0.2021."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000804"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2016.1209483"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2013.786700"},{"key":"e_1_2_8_10_1","unstructured":"EMA.Urorec (Silodosin) Product 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Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:30:15Z","timestamp":1696534215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/hiv.13519"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13519","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"type":"print","value":"1464-2662"},{"type":"electronic","value":"1468-1293"}],"subject":[],"published":{"date-parts":[[2023,6,8]]},"assertion":[{"value":"2022-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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