{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:12:20Z","timestamp":1793913140485,"version":"4.8.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL160332"],"award-info":[{"award-number":["R01HL160332"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01DA053157"],"award-info":[{"award-number":["K01DA053157"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The advent of antiretroviral therapy (ART) has reduced AIDS\u2010related morbidity and mortality among people living with HIV (PLWH). Due to increased survival, PLWH have now been found to be at risk of chronic conditions related to ageing, such as cardiovascular disease (CVD). Hypertension is common in PLWH and is a major risk factor for the development of CVD. We conducted a systematic literature review to evaluate the research evidence on longitudinal blood pressure (BP) trajectories following ART initiation in PLWH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the following databases: PubMed, CINHAL, Scopus, and Web of Science (up to 15 March 2021) for peer\u2010reviewed published studies that reported BP trajectories following ART initiation in PLWH. Three reviewers independently screened all studies by title and abstract. We included articles in English, published up to March 2021, that report office BP trajectories in PLWH initiating ART. A total of 10 publications met our inclusion criteria. Eight studies were prospective cohorts and two were retrospective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine out of 10 studies in the literature reported an increase in systolic BP (4.7\u201310.0\u2009mmHg in studies with a follow\u2010up range of 6\u2009months to 8\u2009years, and 3.0\u20134.7\u2009mmHg\/year in time\u2010averaged studies). In addition, four out of 10 studies reported increases in diastolic BP (2.3\u20138.0\u2009mmHg for a 6\u2009month to 6.8\u2010year follow\u2010up range and 2.3\u2009mmHg\/year).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Systolic BP consistently increases while diastolic BP changes are more heterogeneous following ART initiation in PLWH. However, the studies were highly variable with respect to population demographics, ART regimen and duration, and follow\u2010up time. Nevertheless, given the risks of CVD complications, such as stroke, heart failure and myocardial infarction, associated with elevated BP, results highlight the importance of future research in this area. It will be important to better characterize BP trajectories over time, identify the most critical times for interventions to reduce BP, determine the long\u2010term CVD consequences in PLWH with elevated BP, and understand how different ART regimens may or may not influence BP and CVD disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13524","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T03:09:21Z","timestamp":1689908961000},"page":"1106-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterizing blood pressure trajectories in people living with HIV following antiretroviral therapy: A systematic review"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-7103","authenticated-orcid":false,"given":"Fabrizio","family":"Drago","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Epidemiology Rutgers School of Public Health  Piscataway New Jersey USA"},{"name":"Carter Immunology Center, Department of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Soshnik\u2010Schierling","sequence":"additional","affiliation":[{"name":"Department of Anesthesia NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Cabling","sequence":"additional","affiliation":[{"name":"Department of English, Communication, and Society King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanyaporn","family":"Pattarabanjird","sequence":"additional","affiliation":[{"name":"Carter Immunology Center, Department of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Desderius","sequence":"additional","affiliation":[{"name":"School of Medicine Catholic University of Health and Allied Sciences  Mwanza Tanzania"},{"name":"Department of Internal Medicine Bugando Medical Centre  Mwanza Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-7358","authenticated-orcid":false,"given":"Elias","family":"Nyanza","sequence":"additional","affiliation":[{"name":"School of Public Health Catholic University of Health and Allied Sciences  Mwanza Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Raymond","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Rutgers School of Public Health  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coleen A.","family":"McNamara","sequence":"additional","affiliation":[{"name":"Carter Immunology Center, Department of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Peck","sequence":"additional","affiliation":[{"name":"Center for Global Health, Department of Internal Medicine Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Shiau","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Rutgers School of Public Health  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.Cardiovascular diseases (CVDs).2017. 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