{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T01:35:03Z","timestamp":1787103303619,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Despite the improved survival of patients with AIDS and Kaposi's sarcoma (KS), competing events are a non\u2010negligible issue affecting the survival of such patients. In this study, we explored the prognostic factors of KS\u2010specific and non\u2010KS\u2010specific mortality in patients with AIDS\u2010related KS (AIDS\u2010KS), accounting for competing risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 17\u2009103 patients with AIDS\u2010KS aged 18\u201365\u2009years between 1980 and 2016 from the Surveillance, Epidemiology, and End Results (SEER) 18 registry database. Prognostic factors for KS\u2010specific and non\u2010KS\u2010specific mortality were determined by the Fine and Grey proportional subdistribution hazard model. We built competing risk nomograms and assessed their predictive performance based on the identified prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 12\u2009943 (75.68%) patients died, 1965 (15.50%) of whom died from competing events. The KS\u2010specific mortality rate was 14\u2009835 per 100\u2009000 person\u2010years, and the non\u2010KS specific mortality rate was 2719 per 100\u2009000 person\u2010years. Specifically, age &gt;44\u2009years was associated with an 11% decrease in the subdistribution hazard of KS\u2010specific mortality compared with age &lt;43\u2009years but a 50% increase in the subdistribution hazard of non\u2010KS\u2010specific mortality. Being male was associated with a 26% increase in the subdistribution hazard of KS\u2010specific mortality compared with being female but a 32% decrease in the subdistribution hazard of non\u2010KS\u2010specific mortality. Notably, being in the antiretroviral therapy (ART) era consistently showed a decrease in the subdistribution hazard of both KS\u2010specific and non\u2010KS\u2010specific mortality than being in the pre\u2010ART era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Competing events commonly occurred among patients with AIDS\u2010KS, which deserves further attention to improve the prognosis of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13530","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T05:26:30Z","timestamp":1691990790000},"page":"60-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic factors for competing risk in patients with <scp>AIDS<\/scp>\u2010related Kaposi's sarcoma: A <scp>SEER<\/scp> population\u2010based study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5072-2261","authenticated-orcid":false,"given":"Haili","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengnan","family":"Guo","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Infectious Disease and Biosecurity Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6894","authenticated-orcid":false,"given":"Zhenqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Fudan University  Shanghai China"},{"name":"Shanghai Institute of Infectious Disease and Biosecurity Fudan University  Shanghai China"},{"name":"Yiwu Research Institue Fudan University  Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0060-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25530"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604520"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30179-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0270-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30125-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605756"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29603"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2395"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.920711"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602102"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4187"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71116-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.0501"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916623"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268812000325"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0713"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214506000001293"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.2360"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.9.1201"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0307"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7501"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.315"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.05.123"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017719"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab116"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.03.109"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4046"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.1716"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002050"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.6489"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.02.018"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.11813"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.6757"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.18.1.19929"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32834344e6"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv235"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2014.08.003"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.75"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20887"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14476"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.312"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225692"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-21-0008"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25886"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000655"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145701"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T08:25:50Z","timestamp":1705479950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,13]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/hiv.13530"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13530","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,13]]},"assertion":[{"value":"2023-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}