{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:24:49Z","timestamp":1792499089382,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The European AIDS Clinical Society (EACS) guidelines were revised in 2023 for the 19th time, and all aspects of HIV care were updated.<\/jats:p><\/jats:sec>Key Points of the Guidelines Update<\/jats:title>Version 12.0 of the guidelines recommend the same six first\u2010line treatment options for antiretroviral treatment (ART)\u2010na\u00efve adults as versions 11.0 and 11.1: tenofovir\u2010based backbone plus an unboosted integrase inhibitor or doravirine; abacavir\/lamivudine plus dolutegravir; or dual therapy with lamivudine or emtricitabine plus dolutegravir. The long\u2010acting section has been expanded in the ART and drug\u2013drug interaction (DDI) panels. Tables for preferred and alternative ART in children and adolescents have been updated, as has the section on prevention of vertical transmission, particularly with new guidance for breastfeeding. A new DDI table has been included for the ART and anti\u2010infective drugs used for opportunistic infections, sexually transmitted infections, and other infectious conditions; lenacapavir has been included in all DDI tables. New sections on alcohol use and patient\u2010reported outcome measures (PROMs) have been included in the comorbidity panel, in addition to updates on many relevant topics, such as new resource guidance for deprescribing in people with HIV. Other sections, including travel, cognitive impairment, cancer screening, sexual health, and diabetes have also been revised extensively. The algorithm for the management of acute hepatitis C virus infection has been removed, as current guidelines recommend immediate treatment of all people with recently acquired hepatitis C virus. Updates on vaccination for hepatitis B virus and recommendations for simplification to tenofovir\u2010free two\u2010drug regimens in people with isolated anti\u2010hepatitis B core antibodies are provided. In the opportunistic infections and COVID\u201019 panel, guidance on the management of COVID\u201019 in people with HIV has been updated according to the most up\u2010to\u2010date evidence, and a new section on monkeypox has been added.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In 2023, the EACS guidelines were updated extensively and now include several new sections. The recommendations are available as a free app, in interactive web format, and as a pdf online.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13542","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:30:59Z","timestamp":1697614259000},"page":"1126-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":191,"title":["Major revision version 12.0 of the European AIDS<\/scp> Clinical Society guidelines 2023"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9931-6686","authenticated-orcid":false,"given":"Juan","family":"Ambrosioni","sequence":"first","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Clinic\u2010Fundaci\u00f3 de recerca Clinic Barcelona \u2013 Institut de investigacions Biomediques August Pi i Sunyer Barcelona Spain"},{"name":"CIBERINFEC, Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Levi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St\u2010Louis and Lariboisi\u00e8re Hospitals, APHP University of Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-423X","authenticated-orcid":false,"given":"Jasmini","family":"Alagaratnam","sequence":"additional","affiliation":[{"name":"HIV Medicine & Sexual Health Chelsea & Westminster Hospital NHS Foundation Trust London UK"},{"name":"Section of Virology, Department of Infectious Disease Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Van Bremen","sequence":"additional","affiliation":[{"name":"Department of Medicine I Bonn University Hospital Bonn 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Clinical Research University Hospital Basel and University of Basel Basel Switzerland"},{"name":"Service of Clinical Pharmacology University Hospital Lausanne and University of Lausanne Lausanne Switzerland"},{"name":"Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"HIV Unit, Infectious Diseases Service, Hospital Clinic\u2010Fundaci\u00f3 de recerca Clinic Barcelona \u2013 Institut de investigacions Biomediques August Pi i Sunyer Barcelona Spain"},{"name":"CIBERINFEC, Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-2527","authenticated-orcid":false,"given":"Cristiana","family":"Oprea","sequence":"additional","affiliation":[{"name":"Infectious Diseases and HIV Department, 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