{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:44:48Z","timestamp":1790963088586,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002329","name":"Bundesamt f\u00fcr Gesundheit","doi-asserted-by":"publisher","award":["19.022422"],"award-info":[{"award-number":["19.022422"]}],"id":[{"id":"10.13039\/501100002329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["BSSGI0_155851"],"award-info":[{"award-number":["BSSGI0_155851"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our objective was to obtain long\u2010term data on the incidence of sexually transmitted infections (STIs) and their association with behavioural factors after widespread pre\u2010exposure prophylaxis (PrEP) implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a time\u2010to\u2010event analysis of a national PrEP cohort in Switzerland (SwissPrEPared study). Participants were people without HIV interested in taking PrEP with at least two STI screening visits. Primary outcomes were incidence rate of gonorrhoea, chlamydia, and syphilis. The association between behavioural factors and STI diagnosis was expressed using hazard ratios. We adjusted for testing frequency and calendar year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This analysis included 3907 participants enrolled between April 2019 and April 2022, yielding 3815.7 person\u2010years of follow\u2010up for gonorrhoea (15\u2009134 screenings), 3802.5 for chlamydia (15\u2009141 screenings), and 3858.6 for syphilis (15\u2009001 screenings). The median age was 39\u2009years (interquartile range [IQR] 32\u201347), 93.8% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093664) identified as men who have sex with men (MSM). The incidence was 22.8 (95% confidence interval [CI] 21.3\u201324.4) per 100 person\u2010years for gonorrhoea, 26.3 (95% CI 24.7\u201328.0) for chlamydia, and 4.4 (95% CI 3.8\u20135.1) for syphilis. Yearly incidence rates decreased between 2019 (all bacterial STIs: 81.6; 95% CI 59.1\u2013109.9) and 2022 (all bacterial STIs: 49.8; 95% CI 44.6\u201355.3). Participants reporting chemsex substance use were at higher risk of incident STIs, as were those reporting multiple sexual partners. Younger age was associated with a higher risk of gonorrhoea and chlamydia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Incidence rates of bacterial STIs decreased over time. Young MSM, those with multiple partners, and those using chemsex substances were at increased risk of STIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.13543","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T01:36:46Z","timestamp":1695951406000},"page":"117-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Incidence of sexually transmitted infections and association with behavioural factors: Time\u2010to\u2010event analysis of a large pre\u2010exposure prophylaxis (\n                    <scp>PrEP<\/scp>\n                    ) cohort"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-2948","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9rique","family":"Hovaguimian","sequence":"first","affiliation":[{"name":"Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute University of Zurich  Zurich Switzerland"},{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D.","family":"Kouyos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital of Zurich  Zurich Switzerland"},{"name":"Institute of Medical Virology University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4638-1940","authenticated-orcid":false,"given":"Katharina","family":"Kusejko","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital of Zurich  Zurich Switzerland"},{"name":"Institute of Medical Virology University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel J.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Sigma Research London School of Hygiene and Tropical Medicine  London UK"},{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"Tarr","sequence":"additional","affiliation":[{"name":"Kantonsspital Baselland University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enos","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Ente Ospedialiero Cantonale, Lugano University of Geneva and University of Southern Switzerland  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique L.","family":"Braun","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital of Zurich  Zurich Switzerland"},{"name":"Institute of Medical Virology University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Calmy","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Division of Infectious Diseases Geneva University Hospital  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Notter","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St. Gallen  St. Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Stoeckle","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology University Hospital Basel, University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Surial","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Inselspital, Bern University Hospital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Christinet","sequence":"additional","affiliation":[{"name":"Checkpoint Vaud  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1449-3873","authenticated-orcid":false,"given":"Katharine E. 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