{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:26:46Z","timestamp":1788251206963,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002879","name":"Canadian HIV Trials Network, Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our objective was to report the baseline characteristics of participants in the Canadian HIV and Aging Cohort Study (CHACS) and present amendments to the initial protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CHACS is a multi\u2010centred prospective cohort study that was initially set from 2011 to 2016 and will now continue recruitment until 2024. Four additional years of follow\u2010up have been added, and additional outcomes and covariates will be prospectively collected. Frailty will be assessed using a modified version of the Fried's frailty phenotype. The four interrelated aspects of gender\u2014gender roles, gender identity, gender relationships, and institutionalized gender\u2014will be measured using the GENESIS\u2010PRAXY questionnaire. Diet will be assessed using a validated, web\u2010based, self\u2010administered food frequency questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1049 participants (77% people living with HIV) were recruited between September 2011 and September 2019. Median age at baseline was 54\u2009years (interquartile range 50\u201361). Most participants were male (84%) and white (83%). Compared with participants without HIV, those with HIV were more likely to be male; to report lower education levels and incomes; to be more sedentary; to use tobacco, recreational, and prescription drugs; to report a personal history of cardiovascular diseases; and to be frail.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The new assessments added to the CHACS protocol will allow for an even more detailed portrait of the pathways leading to accentuated aging for people living with HIV. Participants in the CHACS cohort display important differences in socio\u2010economic and cardiovascular risk factors according to HIV serostatus. These imbalances must be taken into account for all further inferential analyses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13550","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:09:11Z","timestamp":1696223351000},"page":"1210-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Baseline characteristics of a prospective cohort study of aging and cardiovascular diseases among people living with <scp>HIV<\/scp>"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5043-426X","authenticated-orcid":false,"given":"Katia","family":"Gigu\u00e8re","sequence":"first","affiliation":[{"name":"Centre de recherche du Centre Hospitalier de l'Universit\u00e9 de Montreal (CRCHUM)  Montreal Quebec Canada"},{"name":"Universit\u00e9 de Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Chartrand\u2010Lefebvre","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre Hospitalier de l'Universit\u00e9 de Montreal (CRCHUM)  Montreal Quebec Canada"},{"name":"Universit\u00e9 de Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Guy","family":"Baril","sequence":"additional","affiliation":[{"name":"Clinique de m\u00e9decine urbaine du Quartier latin  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Conway","sequence":"additional","affiliation":[{"name":"Vancouver ID Research &amp; Care Centre Society  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El\u2010Far","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre Hospitalier de l'Universit\u00e9 de Montreal (CRCHUM)  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Falutz","sequence":"additional","affiliation":[{"name":"Montreal General Hospital  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Harris","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-9777","authenticated-orcid":false,"given":"Mohammad\u2010Ali","family":"Jenabian","sequence":"additional","affiliation":[{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Montreal  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Leipsic","sequence":"additional","affiliation":[{"name":"Providence Health Care Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Loutfy","sequence":"additional","affiliation":[{"name":"Women's College Research Institute  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Mansour","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre Hospitalier de l'Universit\u00e9 de Montreal (CRCHUM)  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"MacPherson","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"Margolese","sequence":"additional","affiliation":[{"name":"CIHR Canadian HIV Trials Network  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Monteith","sequence":"additional","affiliation":[{"name":"Coalition des organismes communautaires qu\u00e9b\u00e9cois de lutte contre le Sida  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie C. 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