{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:36:36Z","timestamp":1792143396575,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate prefrailty and frailty prevalence and associated factors in people living with HIV (PLHIV) from a sex perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study on PLHIV at specialized public health centres in Brazil. Data were obtained from individuals aged \u226550\u2009years using antiretroviral therapy (ART) and with an undetectable viral load through personal interviews, clinical evaluations and medical records. Frailty and prefrailty were characterized using the Fried Frailty Phenotype tool. Multinomial regression models were performed, and the associated factors were selected through the backward stepwise method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 670 patients, 373 men and 297 women were included. The prevalence of frailty and prefrailty was significantly higher for women (16.2% and 56.2%, respectively) than for men (11.5% and 46.4%, respectively). Low socioeconomic and educational level, multimorbidity, depression, subjective cognitive complaints, and low scores on the Mini\u2010Mental State Exam (MMSE) were associated (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) with frailty for both sexes. However, in the sex\u2010specific analysis, while smoking (OR\u2009=\u20093.66, 95% CI: 1.58\u20138.48) and a history of low adherence to ART (OR\u2009=\u20093.10, 95% CI: 1.33\u20137.23) were associated with frailty in men, depression (OR\u2009=\u20093.39, 95% CI: 1.36\u2013 8.44) and the absence of functional dentition (OR\u2009=\u20093.77, 95% CI: 1.36\u2013 10.43) were associated with frailty in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study adds self\u2010reported cognitive complaints as a potential predictor of frailty in both sexes and supports the known deleterious effect of multimorbidity on frailty in adults living with HIV. Furthermore, it suggests that other possible predictors, such as depression, oral health status and adherence to ART, may be sex\u2010specific.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13551","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T04:50:30Z","timestamp":1695876630000},"page":"1222-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Frailty in people 50\u2009years or older living with <scp>HIV<\/scp>: A sex perspective"],"prefix":"10.1111","volume":"24","author":[{"given":"Susana Lilian","family":"Wiechmann","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Internal Medicine Department Universidade Estadual de Londrina  Londrina Brazil"},{"name":"Postgraduate Program in Public Health Universidade Estadual de Londrina  Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-9464","authenticated-orcid":false,"given":"Alexandre Mestre","family":"Tejo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Internal Medicine Department Universidade Estadual de Londrina  Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Victor Silva","family":"In\u00e1cio","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Internal Medicine Department Universidade Estadual de Londrina  Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Eumann","family":"Mesas","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Public Health Universidade Estadual de Londrina  Londrina Brazil"},{"name":"Health and Social Research Center Universidad de Castilla\u2010La Mancha  Cuenca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Mart\u00ednez\u2010Vizca\u00edno","sequence":"additional","affiliation":[{"name":"Health and Social Research Center Universidad de Castilla\u2010La Mancha  Cuenca Spain"},{"name":"Facultad de Ciencias de la Salud Universidad Aut\u00f3noma de Chile  Talca Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Aparecido Sarria","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Public Health Universidade Estadual de Londrina  Londrina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1219445"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13236"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2021.0155"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000798"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac129"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2019.0103"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2020.0113"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-021-03393-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu258"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-8910.2013047004226"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00143-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001790"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002250"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2021.05.008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001507"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215764"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102007000400014"},{"issue":"2","key":"e_1_2_7_21_1","first-page":"57","article-title":"Translation and cultural adaptation of the Minnesota leisure time activities questionnaire in community\u2010dwelling older people","volume":"5","author":"Lustosa LP","year":"2011","journal-title":"Geriatr Gerontol Aging"},{"key":"e_1_2_7_22_1","unstructured":"Brazilian Association of Research Companies (ABEP).Brazil economic classification criteria [Internet] 2019 [cited 2019 Sep 5]. 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