{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:22:14Z","timestamp":1768612934235,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","award":["CO\u2010SW\u2010985\u20105602"],"award-info":[{"award-number":["CO\u2010SW\u2010985\u20105602"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010474","name":"Swiss HIV Cohort Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010474","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PP00P3_211025"],"award-info":[{"award-number":["PP00P3_211025"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["#201369"],"award-info":[{"award-number":["#201369"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010RHUS\u20100003"],"award-info":[{"award-number":["ANR\u201017\u2010RHUS\u20100003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Improving the understanding of the patterns of quantitative hepatitis B surface antigen (qHBsAg) trajectories associated with HBsAg loss is important in light of novel anti\u2010hepatitis B virus agents being developed. We evaluated long\u2010term qHBsAg trajectories in persons with HIV and HBV during tenofovir\u2010containing antiretroviral therapy in the Swiss HIV Cohort Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 29 participants with and 29 without HBsAg loss, defined as qHBsAg &lt;0.05\u2009IU\/mL. We assessed qHBsAg decline during therapy in both groups and used agglomerative hierarchical clustering to identify different qHBsAg trajectory profiles in persons with HBsAg loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time was 11.9\u2009years (IQR 8.4\u201314.1), and the median time to HBsAg loss was 48\u2009months (IQR 12\u201396). Among participants with HBsAg loss, 79% had a qHBsAg decline \u22651 log<jats:sub>10<\/jats:sub> IU\/mL 2\u2009years after starting tenofovir. The trajectories in qHBsAg levels during tenofovir therapy were heterogeneous, characterized by five distinct profiles. Among participants without HBsAg loss, only 7% had a qHBsAg decline \u22651 log<jats:sub>10<\/jats:sub> IU\/ml after 2\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most persons with HIV who experienced HBsAg loss had an early decline in qHBsAg levels, with diverse trajectories during long\u2010term tenofovir therapy. In persons without HBsAg loss, qHBsAg levels remained remarkably stable over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13561","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:21:02Z","timestamp":1697084462000},"page":"291-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Long\u2010term quantitative hepatitis B surface antigen <scp>(HBsAg<\/scp>) trajectories in persons with and without <scp>HBsAg<\/scp> loss on tenofovir\u2010containing antiretroviral therapy"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1015-8947","authenticated-orcid":false,"given":"Lorin","family":"Begr\u00e9","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Graduate School for Health Sciences University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research and Prevention Public Health Service of Amsterdam  Amsterdam The Netherlands"},{"name":"Stichting HIV Monitoring Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Salazar\u2010Vizcaya","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Suter\u2010Riniker","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"B\u00e9guelin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen K.","family":"Rockstroh","sequence":"additional","affiliation":[{"name":"HIV\u2010Clinic, Department of Medicine I University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huldrych F.","family":"G\u00fcnthard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases University Hospital Zurich  Zurich Switzerland"},{"name":"Institute of Medical Virology University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Calmy","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University Hospital Geneva, University of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Cavassini","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Lausanne University Hospital, University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"St\u00f6ckle","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases &amp; Hospital Epidemiology University Hospital Basel, University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Schmid","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology Cantonal Hospital St. Gallen  St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enos","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Regional Hospital Lugano EOC, University of Geneva and University of Southern Switzerland  Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Levrero","sequence":"additional","affiliation":[{"name":"Hepatology Department Hospices Civils de Lyon and University of Claude Bernard Lyon 1 (UCLB1)  Lyon France"},{"name":"UMR Inserm U1052\u2013CNRS 5286, Cancer Research Center of Lyon (CRCL)  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Zoulim","sequence":"additional","affiliation":[{"name":"Hepatology Department Hospices Civils de Lyon and University of Claude Bernard Lyon 1 (UCLB1)  Lyon France"},{"name":"UMR Inserm U1052\u2013CNRS 5286, Cancer Research Center of Lyon (CRCL)  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Wandeler","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andri","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Swiss HIV Cohort Study (SHCS)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001646"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_9_4_1","unstructured":"European AIDS Clinical Society (EACS).EACS guidelines version 11.1.2022Accessed August 24 2023.https:\/\/eacs.sanfordguide.com"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac823"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13071341"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz450"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"163","article-title":"Frequent HBsAg clearance during tenovir therapy in HIV\/HBV coinfection [CROI Abstract 449]. 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