{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:14:48Z","timestamp":1788984888309,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Although widely recommended, data on bictegravir\/emtricitabine\/tenofovir alafenamide (BIC\/FTC\/TAF) efficacy in HIV\u20101\u2010infected children\/adolescents are mainly extrapolated from studies in adults and one paediatric trial in which subjects have good treatment adherence. This study aimed to provide data about the risk of virological failure (VF) and acquired genotypic resistance in children and adolescents receiving BIC\/FTC\/TAF in a real\u2010world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective monocentric study included 74 paediatric patients who received BIC\/FTC\/TAF during \u22656\u2009months in 2019\u20132023. VF was defined as not achieving a plasma viral load &lt;50 copies\/mL within 6\u2009months of BIC\/FTC\/TAF initiation or as experiencing virological rebound \u226550 copies\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients were antiretroviral therapy (ART)\u2010experienced (93.2%), previously exposed to integrase inhibitors (85.1%) and displayed viral suppression at baseline (67.6%). Their median age was 11.2\u2009years [interquartile range (IQR): 8.8\u201315.2]. BIC\/FTC\/TAF introduction reduced treatment burden in most ART\u2010experienced subjects. Genotypic susceptibility score of BIC\/FTC\/TAF was \u22652 in all cases. Median follow\u2010up was 40\u2009months (IQR: 21\u201346). VF occurred in 28 people (37.8%), more frequently in the case of VF versus viral suppression at baseline (68% vs. 26%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). BIC\/FTC\/TAF was interrupted for suspected intolerance in only one case (1.4%). Nucleoside reverse transcriptase inhibitor (NRTI) mutation (T69D\/N) emerged in one patient (3.6% of VF) after 47\u2009months of continuous detectable viraemia while on ART. No acquisition of mutations in the integrase gene was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Because of its high genetic barrier to resistance, BIC\/FTC\/TAF could be especially useful in the paediatric population, in which the risk of poor treatment adherence and VF is high.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13562","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T16:40:21Z","timestamp":1696869621000},"page":"299-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bictegravir\/emtricitabine\/tenofovir alafenamide in paediatrics: Real\u2010life experience from a French cohort (2019\u20132023)"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-8369","authenticated-orcid":false,"given":"P.","family":"Frange","sequence":"first","affiliation":[{"name":"Laboratoire de Microbiologie Clinique H\u00f4pital Necker\u2013Enfants Malades, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"EHU 7328 PACT, Institut Imagine, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Unit\u00e9 d'Immunologie, H\u00e9matologie et Rhumatologie P\u00e9diatriques, H\u00f4pital Necker\u2013Enfants Malades, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Veber","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Immunologie, H\u00e9matologie et Rhumatologie P\u00e9diatriques, H\u00f4pital Necker\u2013Enfants Malades, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Burgard","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie Clinique H\u00f4pital Necker\u2013Enfants Malades, Assistance Publique\u2013H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Blanche","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Immunologie, H\u00e9matologie et Rhumatologie P\u00e9diatriques, H\u00f4pital Necker\u2013Enfants Malades, AP\u2010HP  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Avettand\u2010Fenoel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"INSERM, U1016, CNRS, UMR8104, Institut Cochin  Paris France"},{"name":"Laboratoire de Virologie H\u00f4pital Cochin, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60208-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(21)00265-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70141-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001306"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01474-16"},{"key":"e_1_2_11_7_1","unstructured":"Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.HHS Panel on Antiretroviral Therapy and Medical Management of Children Living with HIV\u2014A Working Group of the Office of AIDS Research Advisory Council (OARAC). 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