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Chan School of Public Health","doi-asserted-by":"publisher","award":["HD052102","P01HD103133"],"award-info":[{"award-number":["HD052102","P01HD103133"]}],"id":[{"id":"10.13039\/100008548","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of body fat on metabolic complications remains poorly understood in young people living with perinatally acquired HIV (YPHIV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our objective was to assess the association of changes in adiposity over 2\u2009years with metabolic outcomes in YPHIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PHACS Adolescent Master Protocol (AMP) study enrolled YPHIV from 2007 to 2009 across 15 US sites, including Puerto Rico. We included YPHIV aged 7\u201319\u2009years with body composition data assessed by whole\u2010body dual\u2010energy X\u2010ray absorptiometry (DXA) at baseline and 2\u2009years later. Metabolic outcomes included homeostatic model assessment of insulin resistance (HOMA\u2010IR) and non\u2010high\u2010density lipoprotein cholesterol (non\u2010HDL\u2010C). We fitted linear regression models to assess the association of increase in body fat over 2\u2009years with metabolic outcomes at years 2 and 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 232 participants had a second DXA and either HOMA\u2010IR or non\u2010HDL\u2010C measured at year 2. Participant characteristics at the first DXA were: age 12\u2009years (9\u201314) [median (Q1\u2013Q3)], 69% Black, and median CD4 count 714 cells\/\u03bcL; 70% with HIV RNA &lt;400 copies\/mL. In adjusted analyses for every 1% increase in body fat from baseline to year 2, HOMA\u2010IR was higher by 1.03\u2010fold at year 3 (95% CI: 1.00, 1.05). We observed that for every 1% increase in body fat from baseline to year 2, non\u2010HDL\u2010C was 0.72\u2009mg\/dL higher at year 2 (95% CI: \u22120.04\u20131.49) and 0.81\u2009mg\/dL higher at year 3 (95% CI: \u22120.05\u20131.66).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increases in adiposity over time may lead to downstream decreased insulin sensitivity and dyslipidaemia in YPHIV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13566","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T01:19:18Z","timestamp":1697505558000},"page":"233-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Longitudinal changes in body fat and metabolic complications in young people with perinatally acquired <scp>HIV<\/scp>"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-9062","authenticated-orcid":false,"given":"Sahera","family":"Dirajlal\u2010Fargo","sequence":"first","affiliation":[{"name":"Case Western Reserve University  Cleveland Ohio USA"},{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise L.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard T.H. 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