{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:46:44Z","timestamp":1792057604664,"version":"4.4.0"},"reference-count":80,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People living with HIV (PLWH) and receiving antiretroviral therapy (ART) have a goal of achieving and maintaining viral suppression; however, the existence of PLWH that show events of low\u2010level viremia (LLV) between 50 and 1000 copies\/mL and with different virological consequences have been observed. Moreover, some reports indicate that LLV status can lead to residual immune activation and inflammation, leading to a higher occurrence of non\u2010AIDS\u2010defining events (nADEs) and other adverse clinical outcomes. Until now, however, published data have shown controversial results that hinder understanding of this phenomenon's actual cause(s) and origin(s). Integrase strand transfer inhibitors (INSTIs)\u2010based therapies could lead to lower LLV over time and, therefore, more effective virological control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This review aims to assess recent findings to provide a view of the clinical significance and management of low\u2010level HIV viremia in the era of INSTIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.13585","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T18:56:17Z","timestamp":1700765777000},"page":"361-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical significance and management of low\u2010level\n                    <scp>HIV<\/scp>\n                    viremia in the era of integrase strand transfer inhibitors"],"prefix":"10.1111","volume":"25","author":[{"given":"Jinchuan","family":"Shi","sequence":"first","affiliation":[{"name":"Affiliated Hangzhou Xixi Hospital Zhejiang University School of Medicine  Hangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxiang","family":"Ying","sequence":"additional","affiliation":[{"name":"Affiliated Hangzhou Xixi Hospital Zhejiang University School of Medicine  Hangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Affiliated Hangzhou Xixi Hospital Zhejiang University School of Medicine  Hangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongdong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hangzhou Xixi Hospital Zhejiang University School of Medicine  Hangzhou PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"HIV.gov.Global Statistics.https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hiv-aids"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3400-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.2.171"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.09.022"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800050105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2021.2004743"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103306"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001678"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180761"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"71","article-title":"Impact of low\u2010level viremia on treatment outcomes during ART \u2013 is it time to revise the definition of virological failure?","volume":"20","author":"Poveda E","year":"2018","journal-title":"AIDS Rev"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad286"},{"key":"e_1_2_10_13_1","volume-title":"European AIDS Clinical Society (EACS). EACS Guidelines, Version 11.0","year":"2021"},{"key":"e_1_2_10_14_1","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents Department of Health and Human Services.Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV.https:\/\/clinicalinfo.hiv.gov\/en\/guidelines\/adult-and-adolescent-arv"},{"key":"e_1_2_10_15_1","unstructured":"World Health Organization (WHO).Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach 2nd edn.2016https:\/\/www.who.int\/publications\/i\/item\/9789241549684"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17025"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000544"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002306"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30681-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz129"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac762"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkac056"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu019"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S388816"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S419610"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2019.0198"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.944990"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010022\u201007417\u2010z"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S387215"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S406188"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2022.0140"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans\u20102023\u2010055860"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13320"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003066"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13250"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12756"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026320"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa413"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600693"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)30418\u20100"},{"key":"e_1_2_10_41_1","unstructured":"Prevention Access Campaign.Undetectable=Untransmittable. Available from:https:\/\/www.preventionaccess.org\/"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)00877\u20102"},{"key":"e_1_2_10_43_1","unstructured":"World Health Organization (WHO).The role of HIV viral suppression in improving individual health and reducing transmission: policy brief.https:\/\/iris.who.int\/bitstream\/handle\/10665\/360860\/9789240055179-eng.pdf"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X20666220216102943"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12397"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.5076"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260941"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.06.021"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1086\/318530"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2023.0015"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0279479"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad219"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003325"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab025"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0289132"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2022.2028677"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2023.2224165"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.02.045"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284767"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.104255"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2022.02.007"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010018\u20101010\u20107"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(20)30099\u20100"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2022.106631"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13265"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002898"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad321"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.11.012"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1161503"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103018(20)30042\u20104"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/09564624221129410"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000003087"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102166"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2021\u20108\u201013"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325958220979817"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010020\u20104837\u2010y"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002588"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.2147\/POR.S127974"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2018.11.016"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI165245"},{"issue":"2","key":"e_1_2_10_81_1","first-page":"226","article-title":"PRESTIGIO RING: \"A 59\u2010year\u2010old HIV\u20101 positive, highly treatment\u2010experienced woman failing darunavir\/ritonavir plus raltegravir\"","volume":"46","author":"Labate L","year":"2023","journal-title":"New Microbiol"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T02:16:31Z","timestamp":1709604991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,22]]},"references-count":80,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/hiv.13585"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13585","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,22]]},"assertion":[{"value":"2023-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}