{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:28:25Z","timestamp":1767922105513,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to assess HIV symptoms from the perspective of both patients and HIV specialists and the impact of discontinuing antiretroviral treatment (ART) on symptomology. We gathered opinions from HIV specialists and people living with HIV about ideal ART parameters and treatment satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ex post\u2010facto cross\u2010sectional surveys were administered to 502 people living with HIV and 101 HIV clinicians in Spain (18 sites).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of participants with HIV was 43.2\u2009years, 74.5% were male, and 91.6% had an undetectable viral load. The mean time since initiation of ART was 10.2\u2009years. Between 54% and 67% of people living with HIV reported experiencing nervousness or anxiety, sadness, fatigue, sleep problems, or muscle\/joint pain during the preceding 4\u2009weeks. However, only 22%\u201327% of specialists acknowledged the presence of these symptoms. The most bothersome symptoms were related to mental health or the central nervous system. There were significant differences between the burden of symptoms reported by people living with HIV and those acknowledged by specialists. The symptoms that more frequently caused ART discontinuation were depression, dizziness, and sleep problems. Both people living with HIV and specialists prioritized ART efficacy and low toxicity, but their importance ratings differed for 5 of the 11 ART characteristics assessed. People living with HIV rated their satisfaction with ART at a mean (\u00b1 standard deviation) of 8.9 \u00b1\u20091.5 out of 10, whereas HIV specialists rated it lower, at 8.3 \u00b1\u20090.7 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite advances in HIV care and treatment, a large proportion of patients still experience symptoms. HIV specialists may not be fully aware of these. People living with HIV and HIV specialists are, overall, satisfied with ART. However, the importance they place on different ART characteristics may vary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13609","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T11:34:47Z","timestamp":1705059287000},"page":"565-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Perspectives of people with <scp>HIV<\/scp> and <scp>HIV<\/scp> clinicians on characteristics of antiretroviral treatment and <scp>HIV<\/scp>\u2010related symptoms"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-4071","authenticated-orcid":false,"given":"M. Jos\u00e9","family":"Galindo Puerto","sequence":"first","affiliation":[{"name":"Spanish AIDS Interdisciplinary Society (SEISIDA)  Madrid Spain"},{"name":"Unit of Infectious Diseases Hospital Cl\u00ednico Universitario de Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-0346","authenticated-orcid":false,"given":"J.","family":"Puig","sequence":"additional","affiliation":[{"name":"Spanish AIDS Interdisciplinary Society (SEISIDA)  Madrid Spain"},{"name":"Fundaci\u00f3n Llucha contra las Infecciones, Nurecare\u2010IGTP, Hospital Germans Trias  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-4124","authenticated-orcid":false,"given":"J. 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