{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:33:51Z","timestamp":1769078031374,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Dolutegravir + rilpivirine (DTG\u2009+\u2009RPV) is an effective antiretroviral therapy regimen approved in clinical guidelines as a switch therapy for virologically suppressed people with HIV. Our study aimed to compare the effectiveness and tolerability of DTG\u2009+\u2009RPV in women and men in real\u2010world clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective analysis of treatment\u2010experienced people with HIV from a large HIV unit who switched to DTG\u2009+\u2009RPV. We analysed treatment effectiveness, rates of adverse events and discontinuation, and metabolic changes after 48\u2009weeks of treatment. HIV\u2010RNA levels &lt;50 copies\/mL were analysed at 48\u2009weeks using both intention\u2010to treat analysis (where missing data were interpreted as failures) and per\u2010protocol analysis (excluding those with missing data or changes due to reasons other than virological failure). Outcomes were compared between women and men based on sex at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 307 patients were selected (71 women and 236 men). No transgender people were included. At baseline, women had lived with HIV infection and received antiretroviral therapy for longer than men (23.2 vs 17.4\u2009years and 18.9 vs 14.2\u2009years, respectively). In the intention\u2010to\u2010treat analysis, 74.6% (95% confidence interval [CI] 63.4\u201383.3%) of women and 83.5% (95% CI 78.2\u201387.7) of men had HIV\u2010RNA\u2009&lt;50 copies\/mL. In the per\u2010protocol analysis, 96.4% (95% CI 87.7\u201399) of women and 99% (95% CI 98.9\u201399.7) of men had HIV\u2010RNA levels &lt;50 copies\/mL. Two women and two men had HIV\u2010RNA &gt;50 copies\/mL at 48\u2009weeks. Discontinuation due to adverse events was more frequent in women than in men: 12.7% vs 7.2% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.02). Neuropsychiatric and gastrointestinal events were the most frequently reported. A median (interquartile range) weight gain of 1.9 kg (0\u20134.2) in women and 1.2 kg (\u22121\u20133.1) in men was reported (median of differences between baseline visit and week 48); the remaining changes in metabolic parameters were neutral.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DTG\u2009+\u2009RPV exhibited good and similar virological effectiveness in women and men in real\u2010world settings. However, poorer tolerability and more treatment interruptions were observed in women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13617","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T07:01:40Z","timestamp":1708498900000},"page":"684-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex differences in the effectiveness and tolerability of dolutegravir plus rilpivirine as a switch strategy in people living with HIV"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5251-2161","authenticated-orcid":false,"given":"Luis","family":"Ramos\u2010Ruperto","sequence":"first","affiliation":[{"name":"HIV Unit, Internal Medicine Department La Paz\u2010Carlos III University Hospital, IdiPaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-5544","authenticated-orcid":false,"given":"Maria 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Mican","sequence":"additional","affiliation":[{"name":"HIV Unit, Internal Medicine Department La Paz\u2010Carlos III University Hospital, IdiPaz  Madrid Spain"},{"name":"CIBER de Enfermedades Infecciosas CIBER INFECC Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Montejano","sequence":"additional","affiliation":[{"name":"HIV Unit, Internal Medicine Department La Paz\u2010Carlos III University Hospital, IdiPaz  Madrid Spain"},{"name":"CIBER de Enfermedades Infecciosas CIBER INFECC Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Delgado\u2010Hierro","sequence":"additional","affiliation":[{"name":"HIV Unit, Internal Medicine Department La Paz\u2010Carlos III University Hospital, IdiPaz  Madrid 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