{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T13:53:14Z","timestamp":1782568394329,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AAI21058\u2010001\u201001000"],"award-info":[{"award-number":["AAI21058\u2010001\u201001000"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH132356"],"award-info":[{"award-number":["R01MH132356"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH130197"],"award-info":[{"award-number":["R01MH130197"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Immune dysregulation persists in people with HIV (PWH) on antiretroviral therapy (ART) and may lead to accelerated vascular ageing and cardiovascular disease (CVD). While delayed time to initiation of ART has been linked to worse cardiovascular outcomes, the effect of ART initiation during acute infection on these outcomes is not well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were enrolled from the SEARCH010\/RV254 acute HIV (AHI) and HIV\u2010NAT chronic HIV (CHI) cohorts in Thailand. Participants with 6\u2010year follow\u2010up and viral suppression (viral load\u2009&lt;\u200950 copies\/\u03bcL) at follow\u2010up were included. Both unmatched cohorts and age and gender\u2010matched cohorts were analysed. Demographics, HIV laboratories, and cardiovascular risk factors from enrolment and 6\u2010year follow\u2010up were obtained from electronic records. Framingham Risk Score (FRS), vascular age (VA), vascular age deviation (VAD), and 10\u2010year atherosclerotic cardiovascular disease (ASCVD) risk were calculated from previously published equations. Vascular outcomes in AHI and CHI cohorts were compared, and univariable and multivariable linear regression analyses were used to investigate risk factors associated with worse vascular scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 373 AHI participants and 608 CHI participants were identified. AHI participants were of younger age, had a higher prevalence of syphilis and a lower prevalence of prior hepatitis B, tuberculosis, diabetes, and hypertension. Higher CD4 T\u2010cell and lower CD8 T\u2010cell counts were seen in the AHI cohort at enrolment and 6\u2010year follow\u2010up. In all participants, the AHI cohort had a lower median FRS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and VA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but higher VAD (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). However, in matched cohorts, no differences were found in FRS\u2010based outcomes. In all participants, higher VAD after 6\u2009years of ART was associated with higher body mass index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and higher CD4 count (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), which persisted in multivariable analysis. When FRS components were analysed individually, CD4 count was associated only with male sex and cholesterol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We did not identify differences in FRS\u2010based vascular outcomes at 6\u2009years in matched cohorts of participants who started ART during AHI versus CHI. We identified a correlation between higher CD4 count and worse FRS\u2010based vascular outcomes, which may be driven by underlying metabolic risk factors. Further study is needed to confirm these findings and evaluate underlying mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13621","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T01:49:16Z","timestamp":1708566556000},"page":"725-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Framingham risk score based vascular outcomes in acute versus chronic <scp>HIV<\/scp> cohorts after 6\u2009years of <scp>ART<\/scp>"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5884-9734","authenticated-orcid":false,"given":"Kathryn Brown","family":"Holroyd","sequence":"first","affiliation":[{"name":"Department of Neurology Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-7960","authenticated-orcid":false,"given":"Win Min","family":"Han","sequence":"additional","affiliation":[{"name":"HIV\u2010NAT Thai Red Cross AIDS Research Centre  Bangkok Thailand"},{"name":"Kirby Institute UNSW Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanakorn","family":"Apornpong","sequence":"additional","affiliation":[{"name":"HIV\u2010NAT Thai Red Cross AIDS Research Centre  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Trautmann","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program Walter Reed Army Institute of Research  Silver Spring Maryland USA"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaporn","family":"Gatechompol","sequence":"additional","affiliation":[{"name":"HIV\u2010NAT Thai Red Cross AIDS Research Centre  Bangkok Thailand"},{"name":"Center of Excellence in Tuberculosis, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1906-8171","authenticated-orcid":false,"given":"Akarin","family":"Hiransuthikul","sequence":"additional","affiliation":[{"name":"HIV\u2010NAT Thai Red Cross AIDS Research Centre  Bangkok Thailand"},{"name":"Department of Preventive and Social Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasiwimol","family":"Ubolyam","sequence":"additional","affiliation":[{"name":"HIV\u2010NAT Thai Red Cross AIDS Research Centre  Bangkok Thailand"},{"name":"Center of Excellence in Tuberculosis, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Sacdalan","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation  Bangkok Thailand"},{"name":"Research Affairs Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Sriplienchan","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratchapong","family":"Kanaprach","sequence":"additional","affiliation":[{"name":"SEARCH Research Foundation  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Kerr","sequence":"additional","affiliation":[{"name":"HIV\u2010NAT Thai Red Cross AIDS Research Centre  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchalee","family":"Avihingsanon","sequence":"additional","affiliation":[{"name":"HIV\u2010NAT Thai Red Cross AIDS Research Centre  Bangkok Thailand"},{"name":"Center of Excellence in Tuberculosis, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Spudich","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University  New Haven Connecticut USA"},{"name":"Yale Center for Brain and Mind Health Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University  New Haven Connecticut USA"},{"name":"Yale Center for Brain and Mind Health Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.033369"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036211"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820a0cfc"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062360"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312120924892"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328352ce54"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/655144"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12029"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506816"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2005.044842"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003245"},{"key":"e_1_2_11_14_1","first-page":"605","article-title":"Comparison of predicted cardiovascular risk profiles by different CVD risk\u2010scoring algorithms between HIV\u20101\u2010infected and uninfected adults: a cross\u2010sectional study in Tanzania","volume":"13","author":"Msoka T","year":"2021","journal-title":"HIV AIDS (Auckl)"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2055-6640(20)30688-9"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000616"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad433"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003204"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.005"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199004000-00007"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-28494-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_4_18"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000695"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.08.756"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304146"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/648080"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1613657"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr558"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13165"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T06:21:30Z","timestamp":1717568490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,21]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/hiv.13621"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13621","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,21]]},"assertion":[{"value":"2023-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}