{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T22:35:58Z","timestamp":1771367758163,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Dolutegravir\u2009+\u2009lamivudine (DTG\u2009+\u20093TC) is a first\u2010line regimen for people with HIV. However, there are still concerns about its efficacy in people with tuberculosis (TB)\/HIV due to the lack of available evidence and drug\u2013drug interaction with rifampicin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre retrospective observational case series was conducted in Guangxi Zhuang Autonomous Region, China. We included all people with TB\/HIV on combined use of once\u2010daily (q.d.) dosing DTG\u2009+\u20093TC and rifampicin (RIF)\u2010containing anti\u2010TB regimens between 2020 and 2022. HIV\u2010RNA, CD4 cell counts were collected and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 21 people with HIV (PWH) were included in this study. All the PWH were treatment\u2010na\u00efve and told to take DTG\u2009+\u20093TC q.d. with food. The median age was 53\u2009years, and 71.43% were male. A total of 71.43% PWH had baseline viral load (VL) &gt;\u2009100\u2009000\u2009copies\/mL, and 33.33% had baseline VL greater than 500\u2009000\u2009copies\/mL. Only one PWH had CD4 cell count greater than 200 cells\/\u03bcL, and the median CD4 count was 20 cells\/\u03bcL. A total of 16 PWH started DTG\u2009+\u20093TC after initiation of the RIF\u2010based anti\u2010TB regimen, and the other five PWH initiated DTG + 3TC before the treatment of TB. All the PWH had at least 24\u2009weeks of follow\u2010up visits and all of the TB treatments were successful. A total of 20 PWH (95.24%) achieved viral suppression (VL &lt;50\u2009copies\/mL). All detected viral loads between weeks 24 and 48 were less than 200\u2009copies\/mL. Among the PWH who started DTG\u2009+\u20093TC after the initiation of RIF\u2010based anti\u2010TB regimen, all achieved viral suppression by week 24 except the non\u2010suppressed PWH. CD4 counts were greatly improved after antiretroviral treatment: the median CD4 counts were raised from 20 to 171 cells\/\u03bcL at week 48. No serious adverse events were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This case series preliminarily validates the efficacy of DTG\u2009+\u20093TC q.d. with food when combined with RIF\u2010based anti\u2010TB regimens in people with TB\/HIV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13632","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:34:35Z","timestamp":1710722075000},"page":"754-758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of dolutegravir\u2009+\u2009lamivudine <scp>q.d.<\/scp> with food in people with <scp>TB<\/scp>\/<scp>HIV<\/scp> using a rifampicin\u2010based regimen: A retrospective observational case series"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3370-1629","authenticated-orcid":false,"given":"Yanyun","family":"Dou","sequence":"first","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruichao","family":"Lu","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingsong","family":"Su","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Lan","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihao","family":"Meng","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanfang","family":"Qin","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liling","family":"Huang","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanlong","family":"Xu","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Lv","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Wen","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuanglai","family":"Lan","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zuo","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chest Hospital of Guangxi Zhuang Autonomous Region  Liuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"WHO.Global tuberculosis report 2022. 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