{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:26Z","timestamp":1787014286877,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antiretroviral therapy (ART), which is increasingly used by people with HIV, accounts for significant care costs, particularly because of single\u2010tablet regimens (STRs). This study explored de\u2010simplification to a two\u2010tablet regimen (TTR) for cost reduction. The objectives of this study were: (1) acceptance of de\u2010simplification, (2) patient\u2010reported outcomes, and (3) cost savings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All individuals on Triumeq\u00ae, Atripla\u00ae or Eviplera\u00ae in five HIV clinics in the Netherlands were eligible. Healthcare providers informed individuals of this study. After inclusion, individuals were free to de\u2010simplify. An electronic questionnaire was sent to assess study acceptance, adherence, quality of life (SF12) and treatment satisfaction (HIVTSQ). After 3 and 12\u2009months, questionnaires were repeated. Cost savings were calculated using Dutch drug prices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 283 individuals were included, of whom 55.5% agreed to de\u2010simplify their ART, with a large variability between treatment centres: 41.1\u201374.2%. Individuals who were willing to de\u2010simplify tended to be older, had a longer history of HIV diagnosis, and used more co\u2010medication than those who preferred to remain on an STR regimen. Patient\u2010reported outcomes, including quality of life and treatment satisfaction, showed no significant difference between people with HIV who switched to a TTR and those who remained on an STR regimen. Furthermore, we observed a 17.8% reduction in drug costs in our cohort of people with HIV who were initially on an STR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>De\u2010simplification from an STR to a TTR within the Dutch healthcare setting has been demonstrated as feasible, leads to significant cost reductions and should be discussed with every eligible person with HIV in the Netherlands.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.13655","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T06:40:49Z","timestamp":1715064049000},"page":"1019-1029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["De\u2010simplifying antiretroviral therapy from a single\u2010tablet to a two\u2010tablet regimen: Acceptance, patient\u2010reported outcomes, and cost savings in a multicentre study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1551-7524","authenticated-orcid":false,"given":"P.","family":"Oosterhof","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy OLVG Hospital  Amsterdam The Netherlands"},{"name":"Department of Pharmacy, Radboudumc Research Institute for Medical Innovation (RIMI) Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. G. J. A.","family":"de Zoete","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy OLVG Hospital  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Vanhommerig","sequence":"additional","affiliation":[{"name":"Department of Research and Epidemiology OLVG Hospital  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Langebeek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases Rijnstate Hospital Arnhem  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. H.","family":"Gisolf","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases Rijnstate Hospital Arnhem  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G. W.","family":"van Hulzen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases, Isala Clinics  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J. J.","family":"Lammers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases, Isala Clinics  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Weijsenfeld","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Amsterdam Infection and Immunity Institute, Amsterdam Public Health Research Institute, Amsterdam University Medical Centres University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"van der Valk","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Amsterdam Infection and Immunity Institute, Amsterdam Public Health Research Institute, Amsterdam University Medical Centres University of Amsterdam  Amsterdam The Netherlands"},{"name":"Stichting HIV Monitoring  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Grintjes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Centre for Infectious Diseases Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"van Crevel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Centre for Infectious Diseases Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"van Luin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Meander Medical Centre  Amersfoort The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Brinkman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Infectious Diseases, OLVG  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7279-2818","authenticated-orcid":false,"given":"D. M.","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboudumc Research Institute for Medical Innovation (RIMI) Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"HIV Antiretroviral Therapy","author":"Kemnic TR","year":"2022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32833f3c14"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32834dce6e"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i14.1814"},{"key":"e_1_2_9_7_1","unstructured":"Rijksinstituut voor Volksgezondheid en Milieu (RIVM).Kosten van ziekten; hiv en aids. Bilthoven. Accessed 11 November 2023 [updated 06\u201007\u20102022; cited 2023 Oct 2023]. Available from:https:\/\/www.vzinfo.nl\/soa\/zorguitgaven"},{"key":"e_1_2_9_8_1","unstructured":"Zorginstituut Nederland.Kosten van medicijnen. the Netherlands. Accessed 31 October 2023. Available from:https:\/\/www.medicijnkosten.nl"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2014.928589"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12578"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12701"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239704"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40801-016-0070-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00290109"},{"key":"e_1_2_9_15_1","unstructured":"vanSighemAI BoydA SmitC MatserA van derValkM.Monitoring Report 2022. Human Immunodeficiency Virus (HIV) Infection in The Netherlands. Amsterdam: Stichting HIV Monitoring 2022."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6405-8-5"},{"key":"e_1_2_9_17_1","volume-title":"Generalized Inference in Repeated Measures: Exact Methods in MANOVA and Mixed Models","author":"Weerahandi S.","year":"2004"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-3485.83221"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-046212"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462417696215"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky321"},{"key":"e_1_2_9_22_1","first-page":"115","article-title":"One\u2010pill once\u2010a\u2010day HAART: a simplification strategy that improves adherence and quality of life of HIV\u2010infected subjects","volume":"4","author":"Airoldi M","year":"2010","journal-title":"Patient Prefer Adherence"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2019.1637536"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T04:30:24Z","timestamp":1731990624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,7]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/hiv.13655"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13655","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,7]]},"assertion":[{"value":"2024-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}