{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:56:31Z","timestamp":1787900191121,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>People living with HIV are disproportionately represented among people with severe mpox. Mild and self\u2010limiting conjunctival involvement has been well\u2010documented, and severe ocular complications, including keratitis, corneal scarring, and the associated loss of vision, are increasingly recognized. Tecovirimat is the first\u2010line antiviral therapy for severe mpox, but data around the efficacy of systemic antiviral agents for mpox are limited, particularly in cases of ocular mpox.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>Here, we describe a case of sight\u2010threatening necrotic blepharokeratoconjunctivitis in a person with advanced HIV, requiring an extended course of tecovirimat due to persistent mpox viral shedding for nearly 5 months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13656","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T06:39:58Z","timestamp":1715323198000},"page":"1086-1090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Severe ocular <scp>Mpox<\/scp> in person living with advanced <scp>HIV<\/scp> treated with extended course of tecovirimat"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9896-8682","authenticated-orcid":false,"given":"Lottie","family":"Brown","sequence":"first","affiliation":[{"name":"Department of HIV Medicine Guys and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pippa","family":"Sargent","sequence":"additional","affiliation":[{"name":"Department of HIV Medicine Guys and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriam","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Guys and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"Downie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Guys and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Guys and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"O'Hara","sequence":"additional","affiliation":[{"name":"Department of Infection Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Douthwaite","sequence":"additional","affiliation":[{"name":"Department of Infection Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-698X","authenticated-orcid":false,"given":"Ranjababu","family":"Kulasegaram","sequence":"additional","affiliation":[{"name":"Department of HIV Medicine Guys and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Robbie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Guys and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Aarons","sequence":"additional","affiliation":[{"name":"Department of Infection Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain D.","family":"Milligan","sequence":"additional","affiliation":[{"name":"Department of Infection Guy's and St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00273-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000003231"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2023.e01706"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2022.6253"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2022-322268"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00504-7"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20042963"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705688"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","unstructured":"ISRCTN17461766.Antiviral treatment with tecovirimat for patients managed at home with monkeypox (PLATINUM) [Placebo\u2010controlled randomised trial of tecovirimat in non\u2010hospitalised monkeypox patients (PLATINUM)]. doi:10.1186\/ISRCTN17461766","DOI":"10.1186\/ISRCTN17461766"},{"key":"e_1_2_5_11_1","unstructured":"NCT05534984.Study of tecovirimat for human monkeypox virus (STOMP) [A randomized placebo\u2010controlled double\u2010blinded trial of the safety and efficacy of tecovirimat for the treatment of human monkeypox virus disease].http:\/\/clinicaltrials.gov\/ct2\/show\/NCT05534984"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/09564624231152940"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7209a4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq103"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2003.09.013"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.04.027"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29354"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T09:30:01Z","timestamp":1732008601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/hiv.13656"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13656","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"assertion":[{"value":"2024-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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