{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:47:24Z","timestamp":1768423644524,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies on switching to tenofovir alafenamide (TAF)\u2010based regimens raise concerns about a worse metabolic profile in people with HIV, even though most received tenofovir disoproxil fumarate (TDF) in their previous regimen. This study aims to evaluate changes in lipid fractions, glucose, and serum markers for hepatic steatosis (HS) after switching from a TDF\u2010 or TAF\u2010sparing regimen to bictegravir\/emtricitabine\/TAF (B\/F\/TAF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study of people with HIV who switched to B\/F\/TAF from TDF\u2010 or TAF\u2010sparing regimens between January 2019 and May 2022 with at least 6\u2009months of follow\u2010up. The primary endpoint was the absolute change in lipid fractions at 6\u2009months. Secondary outcomes were changes in lipid fractions at 12\u2009months and changes in other metabolic parameters (glucose, creatinine, and HS based on the triglyceride\u2010to\u2010glucose [TyG] ratio at 6 and 12\u2009months). Changes were analysed using mixed linear regression models with random intercept and time as a fixed effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 259 people with HIV (median age 55 [interquartile range (IQR) 47\u201360] years; 80% male; 88% Caucasian; CD4+ T\u2010cell count 675 [IQR 450\u2013880] cells\/mm<jats:sup>3<\/jats:sup>; 84.3% HIV\u2010RNA &lt;50 copies\/mL). In total, 63 patients (30%) had hypertension, 93 (44%) dyslipidaemia, 30 (14%) diabetes, and 45% obesity\/overweight. Most (60%) switched from integrase inhibitor\u2010based regimens, and 21% switched from a boosted regimen. At 6\u2009months, significant reductions were observed in total cholesterol (\u22127.64\u2009mg\/dL [95% confidence interval (CI) \u221213.52 to \u22121.76; <jats:italic>p<\/jats:italic>\u2009=\u20090.002]), triglycerides (\u221223.4 [95% CI \u221242.07 to \u22124.65]; <jats:italic>p<\/jats:italic>\u2009=\u20090.003), and TyG ratio (\u22120.14 [95% CI \u22120.23 to \u22120.05]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our real\u2010life cohort, the effect of switching TDF\u2010\/TAF\u2010sparing regimens to triple therapy with B\/F\/TAF improved total cholesterol, triglycerides, and serum markers of HS at 6\u2009months and was neutral for the remaining metabolic parameters at 12\u2009months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13659","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T07:53:03Z","timestamp":1715759583000},"page":"1030-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic effects of switching to Biktarvy (B\/F\/<scp>TAF<\/scp>) in patients with <scp>HIV<\/scp>\u20101 treated with antiretroviral regimens that do not include tenofovir disoproxil fumarate (<scp>TDF<\/scp>) or tenofovir alafenamide (<scp>TAF<\/scp>): The Metabic study"],"prefix":"10.1111","volume":"25","author":[{"given":"C.","family":"Busca\u2010Arenzana","sequence":"first","affiliation":[{"name":"HIV Unit, Hospital Universitario de La Paz\u2010Carlos III, IdiPAZ  Madrid Spain"},{"name":"CIBER de Enfermedades Infecciosas CIBER INFEC Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ortega\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"HIV Unit, Hospital Universitario de La Paz\u2010Carlos III, IdiPAZ  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"D\u00edaz\u2010Almir\u00f3n","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, La Paz Research Institute, IdiPAZ  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Montes","sequence":"additional","affiliation":[{"name":"HIV Unit, Hospital Universitario de La Paz\u2010Carlos III, IdiPAZ  Madrid Spain"},{"name":"CIBER de Enfermedades Infecciosas CIBER INFEC Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz","family":"Martin\u2010Carbonero","sequence":"additional","affiliation":[{"name":"HIV Unit, Hospital Universitario de La Paz\u2010Carlos III, IdiPAZ  Madrid Spain"},{"name":"CIBER de Enfermedades Infecciosas CIBER INFEC Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mican","sequence":"additional","affiliation":[{"name":"HIV Unit, Hospital Universitario de La Paz\u2010Carlos III, IdiPAZ  Madrid Spain"},{"name":"CIBER de Enfermedades Infecciosas CIBER INFEC Instituto de Salud Carlos III  Madrid 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