{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:56:35Z","timestamp":1768899395519,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Women with HIV are globally underrepresented in clinical research. Existing studies often focus on reproductive outcomes, seldom focus on older women, and are often underpowered to assess sex\/gender differences. We describe CD4, HIV viral load (VL), clinical characteristics, comorbidity burden, and use of antiretroviral therapy (ART) among women with HIV in the RESPOND study and compare them with those of the men in RESPOND.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RESPOND is a prospective, multi\u2010cohort collaboration including over 34\u2009000 people with HIV from across Europe and Australia. Demographic and clinical characteristics, including CD4\/VL, comorbidity burden, and ART are presented at baseline, defined as the latter of 1 January 2012 or enrolment into the local cohort, stratified by age and sex\/gender. We further stratify men by reported mode of HIV acquisition, men who have sex with men (MSM) and non\u2010MSM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women account for 26.0% (<jats:italic>n<\/jats:italic>\u2009=\u20099019) of the cohort, with a median age of 42.2\u2009years (interquartile range [IQR] 34.7\u201349.1). The majority (59.3%) of women were white, followed by 30.3% Black. Most women (75.8%) had acquired HIV heterosexually and 15.9% via injecting drug use. Nearly half (44.8%) were receiving a boosted protease inhibitor, 31.4% a non\u2010nucleoside reverse transcriptase inhibitor, and 7.8% an integrase strand transfer inhibitor. The baseline year was 2012 for 73.2% of women and &gt;2019 for 4.2%. Median CD4 was 523 (IQR 350\u2013722) cells\/\u03bcl, and 73.6% of women had a VL\u2009&lt;200 copies\/mL. Among the ART\u2010na\u00efve population, women were more likely than MSM but less likely than non\u2010MSM (<jats:italic>p<\/jats:italic> &lt;\u20090.001) to have CD4\u2009&lt;200 cells\/\u03bcL and less likely than both MSM and non\u2010MSM (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) to have VL \u2265100\u2009000 copies\/mL. Women were also more likely to be free of comorbidity than were both MSM and non\u2010MSM (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RESPOND women are diverse in age, ethnicity\/race, CD4\/VL, and comorbidity burden, with important differences relative to men. This work highlights the importance of stratification by sex\/gender for future research that may help improve screening and management guidelines specifically for women with HIV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13662","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:29:55Z","timestamp":1717655395000},"page":"1058-1074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics of women with <scp>HIV<\/scp> in the <scp>RESPOND<\/scp> cohort: A descriptive analysis and comparison to men"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-3808","authenticated-orcid":false,"given":"J.","family":"Hutchinson","sequence":"first","affiliation":[{"name":"The Australian HIV Observational Database (AHOD), The Kirby Institute, UNSW Sydney  Sydney New South Wales 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