{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:24:20Z","timestamp":1785939860825,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>HIV\/hepatitis C virus (HCV) co\u2010infection among people who inject drugs (PWID) remains a global health problem. The goal of our study was to evaluate, in a real\u2010world setting, success rates of sustained virological response (SVR) using direct\u2010acting antivirals (DAAs) to treat a population of PWID living with HCV\/HIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective single\u2010center observational study. We collected demographic, socioeconomic, and clinical data pertaining to HIV and HCV infection in PWID with several barriers to care. We identified risk factors for SVR failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 130 individuals retained to HIV care, we planned HCV treatment in 119\/130 (91.5%); 106\/119 (89.1%) started treatment with DAAs and 100\/106 (94.3%) completed treatment. People not starting treatment were more often in active opioid drug use (odds ratio [OR] 0.25; 95% confidence interval [CI] 0.07\u20130.97, <jats:italic>p<\/jats:italic>\u2009=\u20090.045) and benzodiazepine abuse (OR 0.25; 95% CI 0.07\u20130.95, <jats:italic>p<\/jats:italic>\u2009=\u20090.042). Only 86\/100 (86%) were tested for SVR at 12\u2009weeks (SVR12) and 72\/86 (83.7%) achieved SVR. PWID in opioid substitution programmes tended to return for SVR12 testing more often (54.7% vs. 30%, <jats:italic>p<\/jats:italic>\u2009=\u20090.081). Individuals in active opioid drug use (OR 0.226; 95% CI 0.064\u20130.793, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) or with poor adherence (OR 0.187; 95% CI 0.043\u20130.814, <jats:italic>p<\/jats:italic>\u2009=\u20090.025) were less likely to achieve SVR. At the end of our study period, 113\/119 (95%) treatment\u2010eligible patients remained alive. HCV infection was cured in 68\/113 (61.1%) people.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings underscore the importance of prioritizing combatting substance use to achieve HCV elimination goals. A systematic approach with effort to overcome barriers to receiving and completing treatment and encourage to enrol in opioid substitution programmes if not possible to completely abstain from use, can help increase chances of HCV cure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13681","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T04:33:10Z","timestamp":1718944390000},"page":"1135-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>HCV<\/scp>\u2010<scp>HIV<\/scp> co\u2010infection in people who inject drugs: Barriers to treatment and cure of <scp>HCV<\/scp> infection in the era of <scp>DAAs<\/scp>, a prospective study in Athens, Greece"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-872X","authenticated-orcid":false,"given":"Dimitris","family":"Basoulis","sequence":"first","affiliation":[{"name":"1st Department of Internal 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