{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:07:41Z","timestamp":1785294461604,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the prevalence and cumulative incidence of neuro\u2010retinal\u2010disorders (NRD) in HIV\u2010controllers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective, single\u2010centre, cohort study of people living with HIV (PLWH): elite\u2010controllers, long\u2010term\u2010non\u2010progressors and early diagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study compared \u201cHIV\u2010controllers\u201d (including elite\u2010controllers and long\u2010term\u2010non\u2010progressors), who were not on antiretroviral therapy (ART), and \u201cHIV\u2010treatment\u201d (HIV\u2010infected subjects with a recent diagnosis and on ART). A matched cohort of \u201cnon\u2010HIV subjects\u201d was created. NRD was defined as at least one altered (not normal) ophthalmological parameter (functional or structural). Functional (visual acuity, contrast sensitivity, chromatic vision, visual field) and structural parameters (ganglion cells, macular nerve fibre layer, peripapillary nerve fibre layers, vascular calibre) as well as quality of life (Medical Outcomes Study\u2010HIV Short Form\u201030) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between March 2012 and November 2015, the study included all HIV\u2010controllers (16 elite\u2010controllers, 1 long\u2010term\u2010non\u2010progressor), 11 HIV\u2010treatment and 16 non\u2010HIV. Prevalence of NRD at baseline was 88.2% (15\/17, 95% CI: 65.7%\u201396.7%), 90.9% (10\/11, 95% CI: 62.3%\u201398.4%) and 56.3% (9\/16, 95% CI: 33.2%\u201376.9%), respectively. Cumulative incidence at 3\u2009years was 50% (1\/2), 100% (1\/1) and 33.3% (2\/6), respectively. None of the participants manifested ocular clinical symptoms. Three years later, prevalence of NRD was 92.3% (12\/13, 95% CI: 66.7%\u201398.6%), 75% (6\/8, 95% CI: 40.9%\u201392.9%) and 50.0% (7\/14, 95% CI: 26.8%\u201373.2%), respectively. Contrast sensitivity and structural parameters were globally the most affected among PLWH. Quality of life (total score) [median (interquartile range)] at baseline and 3\u2009years was 82 (71\u201389) and 74 (63.5\u201379.25) in HIV\u2010controllers and 80 (73\u201388) and 88 (83\u201392) in HIV\u2010treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HIV\u2010controllers and those individuals on ART presented a higher percentage of NRD than non\u2010HIV. Our results suggest that NRD could be a biomarker of ocular aging among PLWH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13685","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T10:07:18Z","timestamp":1720519638000},"page":"1192-1202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional and structural neuroretinal disorders in HIV Controllers. Prospective cohort study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6672-9481","authenticated-orcid":false,"given":"Susana","family":"Ruiz\u2010Bilbao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Hospital Universitari Germans Trias i Pujol  Barcelona Spain"},{"name":"Lluita contra les Infeccions Foundation  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5049-1379","authenticated-orcid":false,"given":"Sebastian","family":"Videla","sequence":"additional","affiliation":[{"name":"Lluita contra les Infeccions Foundation  Badalona Spain"},{"name":"Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine, and Health Sciences, IDIBELL University of Barcelona, L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Universitari Germans Trias i Pujol  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montse","family":"Soler","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Universitari Germans Trias i Pujol  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puig","family":"Jordi","sequence":"additional","affiliation":[{"name":"Lluita contra les Infeccions Foundation  Badalona Spain"},{"name":"Department of Infectious Disease Hospital Universitari Germans Trias i Pujol  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Grizolli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Universitari Germans Trias i Pujol  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eug\u00e8nia","family":"Negredo","sequence":"additional","affiliation":[{"name":"Lluita contra les Infeccions Foundation  Badalona Spain"},{"name":"Department of Infectious Disease Hospital Universitari Germans Trias i Pujol  Barcelona Spain"},{"name":"Universitat de Vic \u2010 Universitat Central de Catalunya (UVic\u2010UCC)  Catalonia Spain"},{"name":"CIBERINFEC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-9548","authenticated-orcid":false,"given":"Jordi","family":"Castellvi\u2010Manent","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hospital Universitari Germans Trias i Pujol  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4081\/idr.2012.3853"},{"key":"e_1_2_10_3_1","volume-title":"Practical Guide to AIDS. Clinic, Diagnosis and Treatment","author":"Clotet B","year":"2017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18537"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-111815-114550"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181deaf4d"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074712"},{"issue":"5","key":"e_1_2_10_8_1","first-page":"789","article-title":"Retinal nerve fiber layer changes based on historic CD4 nadir among HIV positive patients undergoing glaucoma evaluation","volume":"12","author":"Van Tassel SH","year":"2019","journal-title":"Int J Ophthalmol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23334"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2019.1704024"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001441"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30303-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.044289"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.07.037"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/646609"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofu117"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32832b514b"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109791"},{"issue":"6","key":"e_1_2_10_19_1","first-page":"OC01","article-title":"Study of retinal nerve fibre layer thickness and visual contrast sensitivity in HIV positive individuals","volume":"11","author":"Paul R","year":"2017","journal-title":"J Clin Diagnostic Res"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(74)90457-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(74)90458-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90525-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.27.3.143.16049"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.08.028"},{"key":"e_1_2_10_25_1","first-page":"245","article-title":"Mechanisms of virologic control and clinical characteristics of HIV+ elite\/viremic controllers","volume":"90","author":"Gonzalo\u2010Gil E","year":"2017","journal-title":"Yale J Biol Med"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-42"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1157\/13048856"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.09.019"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-022-02488-7"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073694"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132996"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-011-1735-4"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31821502e1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-199512000-00006"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000070634"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2015.0091"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229977"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.08.027"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.11.026"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051405"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.11.008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001144"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506816"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:55:36Z","timestamp":1731372936000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/hiv.13685"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13685","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"2023-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}