{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:32:32Z","timestamp":1790332352179,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Prevention of cardiovascular disease is a major issue in the current management of people living with HIV. Concern is growing about the metabolic impact of integrase strand transfer inhibitors (INSTIs), which could lead to an increased risk of diabetes, but the data are conflicting. This is an updated version of our previous analysis, with longer follow\u2010up and new molecules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated the incidence of new\u2010onset diabetes in people living with HIV starting combined antiretroviral therapy with an INSTI compared with non\u2010nucleoside reverse transcriptase inhibitors and protease inhibitors. Data were collected from the Dat'AIDS cohort study, a collaboration of 30 HIV treatment centres in France. We used a propensity score\u2010based inverse probability of treatment weighting approach to adjust for baseline characteristics between the two groups (INSTI and non\u2010INSTI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2009 and 2021, a total of 12\u2009150 people living with HIV were included. The incidence of diabetes was higher in the INSTI group than in the non\u2010INSTI group (hazard ratio 1.38; 95% confidence interval 1.07\u20131.77; <jats:italic>p<\/jats:italic>\u2009=\u20090.012). Regardless of the third drug, but to a greater extent for INSTIs, we observed a peak of new\u2010onset diabetes in the year following initiation of combined antiretroviral therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of diabetes was higher in people treated with integrase inhibitors than in those receiving other third agents. This increased risk occurred both during the first year of treatment and in the longer term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hiv.13698","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:13:30Z","timestamp":1724890410000},"page":"166-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased incidence of diabetes in people living with <scp>HIV<\/scp> treated with first\u2010line integrase strand transfer inhibitors: A French multicentre retrospective study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2383-7415","authenticated-orcid":false,"given":"Axel","family":"Ursenbach","sequence":"first","affiliation":[{"name":"Le Trait d'Union, HIV\u2010Infection Care Center H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Sireyjol","sequence":"additional","affiliation":[{"name":"Statoscop  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Delpierre","sequence":"additional","affiliation":[{"name":"CERPOP, UMR1295, INSERM Universit\u00e9 Toulouse III Paul\u2010Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Duvivier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, AP\u2010HP, Necker Hospital, Department of Infectious Diseases, INSERM, U1016, Institut Cochin, CNRS, UMR8104, Necker\u2010Pasteur Infectiology Center, IHU Imagine Institut Pasteur, Necker\u2010Pasteur Infectiology Center  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2264-4822","authenticated-orcid":false,"given":"Laurent","family":"Hocqueloux","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department CHU d'Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rey","sequence":"additional","affiliation":[{"name":"Le Trait d'Union, HIV\u2010Infection Care Center H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Dat'AIDS Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz407"},{"key":"e_1_2_8_4_1","article-title":"Weight gain associated with integrase stand transfer inhibitor use in women","author":"Kerchberger AM","year":"2019","journal-title":"Clin Infect Dis"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25702"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac355"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003348"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa330"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003548"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2022-003136"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2014.0037"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.26123"},{"key":"e_1_2_8_13_1","unstructured":"2019 ESC Guidelines on diabetes pre\u2010diabetes and cardiovascular diseases developed in collaboration with the EASD | European Heart Journal | Oxford Academic [Internet]. [cited 2024 Jan 23]. Available from:https:\/\/academic.oup.com\/eurheartj\/article\/41\/2\/255\/5556890?login=true#202785332"},{"issue":"5","key":"e_1_2_8_14_1","first-page":"3","article-title":"Bictergravir alters glucose tolerance and metabolism","volume":"24","author":"Gisbert\u2010Ferr\u00e1ndiz L","year":"2023","journal-title":"EACS Abstracts HIV Med"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462416675107"},{"key":"e_1_2_8_16_1","article-title":"Bictegravir\u2010based antiretroviral therapy\u2010associated accelerated hyperglycemia and diabetes mellitus. Open forum","volume":"8","author":"Nolan NS","year":"2021","journal-title":"Infect Dis"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"19","article-title":"Raltegravir\u2010associated diabetic ketoacidosis in a patient with HIV infection: a case report","volume":"43","author":"Horikawa M","year":"2018","journal-title":"Tokai J Exp Clin Med"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae406"}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T01:26:38Z","timestamp":1736731598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/hiv.13698"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13698","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,28]]},"assertion":[{"value":"2024-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}