{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:41:23Z","timestamp":1790127683253,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["HIV Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Fostemsavir is a novel attachment inhibitor used with other antiretrovirals in heavily treatment\u2010experienced (HTE) adults with multidrug\u2010resistant HIV\u20101. Real\u2010world immunological and virological responses were assessed in individuals starting fostemsavir in the OPERA cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among adults with HIV\u20101 starting fostemsavir between 2 July 2020 and 1 September 2022, 6\u2010month and 12\u2010month changes in CD4 T\u2010cell count and CD4%, and maintenance\/achievement of viral load (VL) &lt;50 copies\/mL were described and stratified by baseline VL (suppressed: &lt;50 copies\/mL; viraemic: \u226550 copies\/mL) and CD4 count (high: \u2265350 cells\/\u03bcL; low: &lt;350 cells\/\u03bcL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 182 individuals starting fostemsavir, 64% were viraemic (34% low CD4, 30% high CD4) and 36% were suppressed (16% low CD4, 20% high CD4). The suppressed\/low CD4 group had the largest median increases in CD4 count (6\u2010month: 30 cells\/\u03bcL [interquartile range {IQR} 9\u201366], 12\u2010month: 66 cells\/\u03bcL [IQR 17\u2013125]), and CD4% (6\u2010month: 1.0% [IQR \u22120.3\u20132.8], 12\u2010month: 1.9% [IQR 1.3\u20133.9]). Regardless of baseline VL, those with a high baseline CD4 count experienced a greater variability in immunological response than those with low CD4 counts (12\u2010month standard deviation range 172\u2013231 cells\/\u03bcL vs. 69\u201390 cells\/\u03bcL). VL &lt;50 copies\/mL was maintained in most suppressed individuals; nearly half of the viraemic\/high CD4 group and a third of the viraemic\/low CD4 group achieved a VL &lt;50 copies\/mL at either timepoint.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After 6 or 12\u2009months of fostemsavir use, virological response was low in viraemic individuals, although most suppressed individuals did maintain suppression. While immunological response varied across individuals, virologically suppressed HTE individuals with low CD4 counts may benefit from immunological improvements with fostemsavir.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hiv.13700","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T01:38:18Z","timestamp":1724636298000},"page":"17-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunological and virological response to fostemsavir in routine US clinical care: An\n                    <scp>OPERA<\/scp>\n                    cohort study"],"prefix":"10.1111","volume":"26","author":[{"given":"Ricky K.","family":"Hsu","sequence":"first","affiliation":[{"name":"NYU Langone Health  New York New York USA"},{"name":"AIDS Healthcare Foundation  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-4835","authenticated-orcid":false,"given":"Laurence","family":"Brunet","sequence":"additional","affiliation":[{"name":"Epividian  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Lackey","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Gerald","family":"Pierone","sequence":"additional","affiliation":[{"name":"Whole Family Health Center  Vero Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-3689","authenticated-orcid":false,"given":"Brooke","family":"Levis","sequence":"additional","affiliation":[{"name":"Epividian  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-811X","authenticated-orcid":false,"given":"Jennifer S.","family":"Fusco","sequence":"additional","affiliation":[{"name":"Epividian  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassidy","family":"Henegar","sequence":"additional","affiliation":[{"name":"ViiV Healthcare  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vani","family":"Vannappagari","sequence":"additional","affiliation":[{"name":"ViiV Healthcare  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Clark","sequence":"additional","affiliation":[{"name":"ViiV Healthcare  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Fusco","sequence":"additional","affiliation":[{"name":"Epividian  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70550-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit529"},{"key":"e_1_2_11_4_1","volume-title":"Report of the WHO Expert Consultation","author":"WHO Expert 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GalliL GagliardiniR et al.Efficacy and durability of fostemsavir ibalizumab or lenacapavir\u2010including regimens in people living with multidrug\u2010resistant HIV\u20101: results from the PRESTIGIO registry [ePOSTER P.B1.031].19th European AIDS Conference(EACS). Warsaw Poland.2023."},{"key":"e_1_2_11_27_1","volume-title":"Diagnoses of HIV Infection in the United States and Dependent Areas","author":"Centers for Disease Control and Prevention","year":"2023"},{"key":"e_1_2_11_28_1","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents and Department of Health and Human Services.Guidelines for the use of antiretroviral agents in adults and adolescents with HIV.2022:2024."}],"container-title":["HIV Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hiv.13700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T20:26:09Z","timestamp":1736713569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hiv.13700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,25]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/hiv.13700"],"URL":"https:\/\/doi.org\/10.1111\/hiv.13700","archive":["Portico"],"relation":{},"ISSN":["1464-2662","1468-1293"],"issn-type":[{"value":"1464-2662","type":"print"},{"value":"1468-1293","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,25]]},"assertion":[{"value":"2024-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}